| 1 | 4:30.65 | Samantha NadelNorth Shore | North Shore '12 | Saint Anthony's Invitational | 2011 |
| 2 | 4:31.76 | Theresa RushValley Stream North | Valley Stream North '06 | New York State Track & Field Championships | 2006 |
| 3 | 4:32.06 | Reilly SiebertSyosset | Syosset '18 | Section VIII State Qualifier Meet | 2018 |
| 4 | 4:32.12 | Emily LipariRoslyn | Roslyn '10 | Saint Anthony's Invitational | 2010 |
| 5 | 4:34.2 | Emily MengesGarden City | Garden City '10 | Class AA County | 2008 |
| 6 | 4:34.24 | Maeve GoingSacred Heart Academy | Sacred Heart Academy '26 | Deer Park Invitational | 2026 |
| 7 | 4:34.57 | Colleen SchmidtHoly Trinity | Holy Trinity '11 | League Championships | 2010 |
| 8 | 4:34.68 | Zaria HallEast Meadow | East Meadow '26 | Section 8 State Qualifier - Day 2 | 2026 |
| 9 | 4:34.94 | Julia SchrieferWheatley | Wheatley '22 | Section VIII State Qualifier | 2022 |
| 10 | 4:35.42 | Aislinn FrazerFriends Academy (Li) | Friends Academy (Li) '25 | Massapequa Chiefs Invitational - Under The Lights | 2025 |
| 11 | 4:35.79 | Diana VizzaNorth Shore | North Shore '16 | Don Scott Memorial Relays | 2016 |
| 12 | 4:36.54 | Rolanda BellSacred Heart | Sacred Heart '05 | NSCHSAA League Championships | 2005 |
| 13 | 4:36.62 | Colleen SchmditHoly Trinity | Holy Trinity '11 | NSCHSAA League Championships | 2011 |
| 14 | 4:38.0 | Maegan KrifchinJFK Bellmore | JFK Bellmore '06 | Derrick Adkins Classic | 2006 |
| 15 | 4:38.12 | Isabelle HaroucheCold Spring | Cold Spring '15 | New York State Track & Field Championships | 2014 |
| 16 | 4:38.16 | Grace MooreCalhoun | Calhoun '16 | Saint Anthony's Invitational | 2016 |
| 17 | 4:38.28 | Kathleen DiCamilloHoly Trinity | Holy Trinity '05 | NSCHSAA League Championships | 2005 |
| 18 | 4:38.59 | Samantha LawGreat Neck North | Great Neck North '18 | Section VIII County Class 2A - Girls | |
| 19 | 4:38.82 | Kimberly MacKayKellenberg | Kellenberg '11 | League Championships | 2010 |
| 20 | 4:38.92 | Mackenzie SettonJericho | Jericho '22 | Section VIII State Qualifier | 2022 |
| 21 | 4:39.29 | Kara McKennaMassapequa | Massapequa '14 | Stony Brook University - Wolfie Invitational | 2018 |
| 22 | 4:39.34 | Brianna WelchNorth Shore | North Shore '10 | State Qualifier | 2006 |
| 23 | 4:39.40 | Joanna KenneyNorth Shore | North Shore '26 | Section 8 State Qualifier - Day 2 | 2026 |
| 24 | 4:39.70 | Christine AmbrosiniLong Beach | Long Beach '09 | Saint Anthony's Invitational | 2009 |
| 25 | 4:39.80 | Jazmine FrayKellenberg | Kellenberg '15 | NSCHSAA League Championships | 2012 |
| 26 | 4:41.50 | Angeline CaamanoManhasset | Manhasset '21 | 47th Saint Anthony's Invitational | 2018 |
| 27 | 4:41.8 | Christy AmbrosiniLong Beach | Long Beach '09 | State Qualifier | 2008 |
| 28 | 4:41.95 | Ana MarkovinaJericho | Jericho '22 | Section VIII State Qualifier | 2022 |
| 29 | 4:43.39 | Aislnn FrazerFriends Academy (Li) | Friends Academy (Li) | Nassau Coaches Invitational | 2025 |
| 30 | 4:43.54 | Kelsey MalmquistKellenberg | Kellenberg '06 | NSCHSAA League Championships | 2005 |
| 31 | 4:43.64 | Jessica AlessiSyosset | Syosset | Section VIII County Championships Class AAA | 2023 |
| 32 | 4:44.58 | Anaya HallEast Meadow | East Meadow '25 | Section 8 AAA County Championship | 2025 |
| 33 | 4:44.76 | Isabella SpagnoliGreat Neck South | Great Neck South '25 | Massapequa Chiefs Invitational - Under The Lights | 2025 |
| 34 | 4:45.19 | Maureen LewinKellenberg | Kellenberg '19 | Suffolk Coaches Meet | 2019 |
| 35 | 4:45.62 | Taylor RettigMassapequa | Massapequa '16 | Massapequa Under the Lights | 2016 |
| 36 | 4:45.7 | Maddie AdamsGarden City | Garden City '08 | State Qualifier | 2007 |
| 37 | 4:45.80 | Kristina CoiroMacArthur | MacArthur '12 | Girls' Suffolk Coaches Meet | 2012 |
| 38 | 4:46.06 | Stephanie GerlandGarden City | Garden City '16 | Saint Anthony's Invitational | 2014 |
| 39 | 4:46.08 | Joelle FeinbergPort Washington | Port Washington '14 | Section VIII Class County Championships | 2014 |
| 40 | 4:46.26 | Ashley MurphySacred Heart | Sacred Heart '11 | NSCHSAA League Championships | 2011 |
| 41 | 4:46.31 | Carly WoelfelSouth Side | South Side '20 | 47th Saint Anthony's Invitational | 2018 |
| 42 | 4:46.6 | Courtney KellyMepham | Mepham '08 | Division 2B Championships | 2008 |
| 43 | 4:46.6 | Brittney CriscuoloEast Meadow | East Meadow '04 | Class A Counties | 2003 |
| 44 | 4:46.73 | Sophie RosencransNorth Shore | North Shore '21 | Section VIII Division 4A Championships | 2018 |
| 45 | 4:46.81 | Chloe ConnollyNorth Shore | North Shore '26 | Section 8 A County Championship | 2026 |
| 46 | 4:47.16 | Amanda AsheEast Meadow | East Meadow '14 | Saint Anthony's Invitational | 2012 |
| 47 | 4:47.17 | Sophia VukelicMassapequa | Massapequa '26 | Section 8 AAA County Championship | 2025 |
| 48 | 4:48.38 | Fayola AllisonSouth Side | South Side '26 | Section 8 A County Championship | 2026 |
| 49 | 4:48.7 | Samantha BeimMepham | Mepham '09 | State Qualifier | 2008 |
| 50 | 4:48.81 | Caroline ConteSacred Heart | Sacred Heart | Stony Brook University - Wolfie Invitational | 2018 |
| 51 | 4:48.91 | Kaelin McCaffreyOur Lady of Mercy (Chsaa) | Our Lady of Mercy (Chsaa) '24 | St. Anthony's Invitational | 2024 |
| 52 | 4:49.21 | DeAnna MartinValley Stream South | Valley Stream South '19 | Section VIII Division 4A Championships | 2018 |
| 53 | 4:49.54 | Lucy HurtPort Washington | Port Washington '18 | Suffolk Coaches Meet | 2018 |
| 54 | 4:49.92 | Emily O'NeillGarden City | Garden City '16 | Saint Anthony's Invitational | 2011 |
| 55 | 4:49.96 | Celeste TraubJericho | Jericho '17 | Saint Anthony's Invitational | 2014 |
| 56 | 4:50.2 | Katherine MurnaneOceanside | Oceanside '02 | State Qualifier | 2002 |
| 57 | 4:50.31 | Isabella GarraCold Spring Harbor | Cold Spring Harbor '27 | Nassau Coaches Invitational | 2026 |
| 58 | 4:50.4 | Carly ShanahanFarmingdale | Farmingdale '03 | Class A Counties | 2003 |
| 59 | 4:50.45 | Nora BennettKellenberg | Kellenberg '18 | NSCHSAA League Championships | 2018 |
| 60 | 4:50.79 | Maria KoganPort Washington | Port Washington '17 | 46th Saint Anthony's Invitational | 2017 |
| 61 | 4:50.8 | Kerryann BrankerIsland Trees | Island Trees '02 | Class B County | 2002 |
| 62 | 4:50.9 | Michelle DuffyIsland Trees | Island Trees '09 | Class A County | 2008 |
| 63 | 4:50.99 | Kelly DuncanSacred Heart | Sacred Heart '07 | NSCHSAA League Championships | 2005 |
| 64 | 4:51.1 | Emily MarchiniMassapequa | Massapequa '10 | 2009 Nassau Coaches Invitational - Girls | |
| 65 | 4:51.4 | Kinjal ParikhEast Meadow | East Meadow '05 | Class A Counties | 2003 |
| 66 | 4:51.7 | Jackie PearceLevittown Dist. | Levittown Dist. '05 | Class A Counties | 2003 |
| 67 | 4:51.78 | Ashley CarilloPaul D. Schrieber / Port Washi | Paul D. Schrieber / Port Washi | Section VIII County Championships Class AAA | 2023 |
| 68 | 4:52.01 | Julia GlenzLong Beach | Long Beach '28 | Section 8 State Qualifier - Day 2 | 2026 |
| 69 | 4:52.25 | Katherine MarshEast Meadow | East Meadow '19 | Section VIII Division 1B Championships | 2018 |
| 70 | 4:52.72 | Margaret McLoughlinKellenberg | Kellenberg '21 | NSCHSAA Varsity Spring Track Track & Field Championship | 2021 |
| 71 | 4:53.06 | Morgan NerudNorth Shore | North Shore '16 | Saint Anthony's Invitational | 2015 |
| 72 | 4:53.25 | Maya RichardsonKellenberg | Kellenberg '19 | NSCHSAA League Championships | 2018 |
| 73 | 4:53.33 | Deidre LewinKellenberg | Kellenberg '16 | NSCHSAA League Championships | 2015 |
| 74 | 4:53.35 | Claire BohanSouth Side | South Side '24 | Massapequa Chief Invitational - Under The Lights | 2024 |
| 75 | 4:53.36 | Paulina ParsonsManhasset | Manhasset '14 | Section VIII State Qualifier Meet | 2014 |
| 76 | 4:53.52 | Alexandra OsmanNorth Shore | North Shore '14 | Section VIII Class County Championships | 2014 |
| 77 | 4:53.65 | Harmony GrodskyFriends Acad | Friends Acad '14 | New York State Track & Field Championships | 2014 |
| 78 | 4:53.87 | Megan JasinskiCold Spring Harbor | Cold Spring Harbor '25 | Section 8 State Qualifier | 2024 |
| 79 | 4:53.9 | Samantha Rae BeimMepham | Mepham '09 | Class AA County | 2007 |
| 80 | 4:54.0 | Katie DiCamilloHoly Trinity | Holy Trinity '05 | Derrick Adkins Holiday | 2004 |
| 81 | 4:54.1 | Lucia MontefuscoMacArthur | MacArthur '10 | State Qualifier | 2007 |
| 82 | 4:54.1 | Kristen WraithValley Stream South | Valley Stream South '10 | Class A County | 2008 |
| 83 | 4:54.5 | Jean ColemanWantagh | Wantagh '02 | Class B County | 2002 |
| 84 | 4:54.59 | Charlotte HeymOceanside | Oceanside '28 | Section 8 AAA County Championship | 2025 |
| 85 | 4:54.67 | Elle RichesSacred Heart Academy | Sacred Heart Academy '27 | NSCHSAA & NSCHSGAA Easter Classic | 2025 |
| 86 | 4:54.7 | Kathleen DuranteFriends Academy | Friends Academy '07 | Conference IVB | 2007 |
| 87 | 4:54.90 | Jen CampbellFarmingdale | Farmingdale '02 | Derrick Adkins Classic | 2002 |
| 88 | 4:55.08 | Kayla HawkinsOur Lady of Mercy (Chsaa) | Our Lady of Mercy (Chsaa) '23 | Valley Stream Challenge Invitational | 2023 |
| 89 | 4:55.16 | Kayleigh CaggianoManhasset | Manhasset '16 | Section VIII State Qualifier Meet | 2015 |
| 90 | 4:55.40 | Ali KrifchinJFK Bellmore | JFK Bellmore '05 | Saint Anthony's Invitational | 2004 |
| 91 | 4:55.56 | Marie NaudusSacred Heart | Sacred Heart '21 | NSCHSAA League Championships | 2018 |
| 92 | 4:55.78 | Gabriella VezzaNorth Shore | North Shore '13 | Saint Anthony's Invitational | 2010 |
| 93 | 4:55.9 | Jennifer FloresEast Meadow | East Meadow '10 | State Qualifier | 2007 |
| 94 | 4:55.9 | Lauren GengoLong Beach | Long Beach '02 | Division IB | 2002 |
| 95 | 4:55.94 | Pollyanna VelascoHoly Trinity | Holy Trinity '14 | NSCHSAA League Championships | 2014 |
| 96 | 4:56.1 | Amanda SchmidtMassapequa | Massapequa '11 | State Qualifier | 2008 |
| 97 | 4:56.13 | Daniela LoCastroCold Spring | Cold Spring '16 | Section VIII Class County Championships | 2014 |
| 98 | 4:56.21 | Ariana MadeiraCold Spring Harbor | Cold Spring Harbor '29 | Division 3B Championship | 2026 |
| 99 | 4:56.23 | Valeria PaezGeorge H. Hewlett | George H. Hewlett '27 | Section 8 AA County Championship | 2026 |
| 100 | 4:56.35 | Emily MoehringerMepham | Mepham '21 | 47th Saint Anthony's Invitational | 2018 |
