| 1 | 59.37 | Donna JeantyBrentwood | Brentwood '10 | Section XI Individual Championships | 2010 |
| 2 | 59.61 | Janet MellorMount Sinai | Mount Sinai '10 | Section XI Individual Championships | 2010 |
| 3 | 59.97 | Jessica GelibertBay Shore | Bay Shore '12 | Girls Division Championship Meet | 2012 |
| 4 | 61.98 | Janie TurekMount Sinai | Mount Sinai '11 | Section XI Individual Championships | 2011 |
| 5 | 62.40 | Katherine SiricoSt. Anthony's | St. Anthony's '07 | SA Inv results 2 | |
| 6 | 1:02.50 | Ryan WoolleySt. John the Baptist | St. John the Baptist '10 | League Championships | 2010 |
| 7 | 1:02.55 | Danielle SimonettiEast Islip | East Islip '26 | Section XI County 3A Championships 2024 | 2024 |
| 8 | 1:02.56 | Gabriella AsareBrentwood | Brentwood | Section XI State Qualifer Day 2 | 2026 |
| 9 | 62.68 | Shannon AhernKings Park | Kings Park '14 | Section XI Individual Championships | 2014 |
| 10 | 1:02.73 | Bella GaleasSachem East | Sachem East | Section XI State Qualifer | 2025 |
| 11 | 63.07 | Michele LauerRocky Point | Rocky Point '05 | Section XI Individual Championships | 2004 |
| 12 | 63.12 | Kathleen CibulsBayport-Blue Point | Bayport-Blue Point '16 | Saint Anthony's Invitational | 2015 |
| 13 | 1:03.17 | Michelle BrutusLongwood | Longwood '07 | New York State Track & Field Championships | 2006 |
| 14 | 63.20 | Kaitlyn McDonaldRocky Point | Rocky Point '14 | Section XI Individual Championships | 2014 |
| 15 | 63.23 | Jessica PichaShoreham-Wading River | Shoreham-Wading River '04 | Section XI Individual Championships | 2004 |
| 16 | 63.25 | Olivia AbbateSt. Anthony's | St. Anthony's '10 | Saint Anthony's Invitational | 2010 |
| 17 | 1:03.28 | Niomi AllisonWest Babylon | West Babylon | Section XI State Qualifier | 2024 |
| 18 | 63.33 | Kaitlyn FamigliettiSachem East | Sachem East '18 | Section XI State Qualifier Championships | 2018 |
| 19 | 63.34 | Kayleigh RobinsonMount Sinai | Mount Sinai '19 | Section XI State Qualifier Championships | 2018 |
| 20 | 63.60 | Tara HernandezNorth Babylon | North Babylon '16 | Saint Anthony's Invitational | 2015 |
| 21 | 63.65 | Brianna ReidBrentwood | Brentwood '12 | Section XI Individual Championships | 2011 |
| 22 | 1:03.70 | Dara SmithComsewogue | Comsewogue '14 | Stony Brook University - Wolfie Invitational | 2016 |
| 23 | 63.72 | Darleen EiermannBay Shore | Bay Shore '10 | Girls Division Championship Meet | 2010 |
| 24 | 63.79 | Brittany MailanderEastport-South Manor | Eastport-South Manor '10 | Section XI Individual Championships | 2010 |
| 25 | 63.94 | Gabby GriffinComsewogue | Comsewogue '18 | Section XI State Qualifier Championships | 2018 |
| 26 | 64.12 | Nataly RamirezBrentwood | Brentwood '17 | 46th Saint Anthony's Invitational | 2017 |
| 27 | 64.24 | Kaitlin SullivanKings Park | Kings Park '08 | Section XI Individual Championships | 2008 |
| 28 | 64.25 | Shana HarrisBrentwood | Brentwood '04 | Section XI Girls Team Championships | 2004 |
| 29 | 64.26 | Kaitlyn ChandrikaMount Sinai | Mount Sinai '21 | Suffolk Coaches Meet | 2019 |
| 30 | 1:04.40 | Adetola GoldMt. Sinai | Mt. Sinai '29 | Section XI State Qualifer Day 1 | 2026 |
| 31 | 64.43 | Ryan WooleySt. John the Baptist | St. John the Baptist '10 | NSCHSAA League Championships | 2009 |
| 32 | 1:04.43 | Brooke PfeifferLongwood | Longwood | Section XI State Qualifer Day 2 | 2026 |
| 33 | 1:04.52 | Alexandra GeositsDeer Park | Deer Park | Section XI State Qualifier | 2024 |
| 34 | 64.64 | Bailey WalkerBayport-Blue Point | Bayport-Blue Point '13 | Section XI Individual Championships | 2011 |
| 35 | 64.65 | Colleen MurphyWard Melville | Ward Melville '09 | Section XI Individual Championships | 2009 |
| 36 | 1:04.79 | Siara GuevaraMiller Place | Miller Place '18 | Stony Brook Snowflake Classic | 2023 |
| 37 | 64.84 | Colleen GribbinConnetquot | Connetquot '05 | Girls Division Championship Meet | 2005 |
| 38 | 64.87 | Kim PortierBay Shore | Bay Shore '05 | Girls Division Championship Meet | 2005 |
| 39 | 1:04.94 | Elaina CarelusIslip | Islip '29 | Section XI State Qualifer Day 2 | 2026 |
| 40 | 1:04.99 | Gianna MarquezDeer Park | Deer Park '22 | Long Island Meet of Champions at St. Anthonys | 2022 |
| 41 | 1:05.00 | Asia ChenBrentwood | Brentwood '16 | Derrick Adkins Holiday Classic | 2016 |
| 42 | 65.12 | Briana ThompsonBay Shore | Bay Shore '08 | Girls SQ Results 2B | 2006 |
| 43 | 65.13 | Olivia SchumannMercy | Mercy '11 | Section XI Individual Championships | 2011 |
| 44 | 65.17 | Bryana PadulaConnetquot | Connetquot '17 | Westhampton Beach Invitational | 2016 |
| 45 | 65.23 | Stephanie QuinnNorthport | Northport '12 | Girls Division Championship Meet | 2012 |
| 46 | 65.24 | Amanda FilibertoNorthport | Northport '07 | Girls SQ Results 2B | 2006 |
| 47 | 65.26 | Ja'Lenrose DeFilippisWest Babylon | West Babylon '20 | Section XI State Qualifier Championships | 2018 |
| 48 | 65.28 | Melodee RileyRiverhead | Riverhead '12 | Westhampton Beach Invitational | 2010 |
| 49 | 65.28 | Amanda FamularoSayville | Sayville '13 | Girls Division Championship Meet | 2012 |
| 50 | 65.38 | Brittany LucatuortoWard Melville | Ward Melville '10 | Section XI Individual Championships | 2009 |
| 51 | 65.40 | Melissa RibackWest Babylon | West Babylon '15 | Section XI Individual Championships | 2014 |
| 52 | 65.44 | Olicia WilliamsSt. Anthony's | St. Anthony's '12 | NSCHSAA League Championships | 2012 |
| 53 | 65.45 | Christine KennedyHalf Hollow Hills West | Half Hollow Hills West '08 | Section XI Individual Championships | 2008 |
| 54 | 65.48 | Danae GloverNorth Babylon | North Babylon '14 | Girls Division Championship Meet | 2014 |
| 55 | 65.51 | Alex KoumasHuntington | Huntington '16 | Girls Division Championship Meet | 2014 |
| 56 | 1:05.57 | Savanna EdwardsSachem East | Sachem East '24 | Section XI State Qualifier | 2024 |
| 57 | 1:05.62 | Carly StriningSayville | Sayville | North Babylon Invitational | 2024 |
| 58 | 1:05.66 | Lauren TrejoSachem East | Sachem East '21 | Section XI Girls Division Championships | 2018 |
| 59 | 65.69 | Molly McLeanEast Islip | East Islip '09 | Section XI Individual Championships | 2008 |
| 60 | 65.69 | Crystal HendersonLongwood | Longwood '15 | Section XI Individual Championships | 2014 |
| 61 | 65.73 | Casey HasherBayport-Blue Point | Bayport-Blue Point '13 | Westhampton Beach Invitational | 2013 |
| 62 | 1:05.74 | Brooke HylandHalf Hollow Hills East (Hhh) | Half Hollow Hills East (Hhh) '25 | Don Bohlinger Invitational | 2025 |
| 63 | 1:05.75 | Skylar PapeleSachem East | Sachem East '19 | Section XI Girls Division Championships | 2018 |
| 64 | 1:05.77 | Samantha SturgessWard Melville | Ward Melville '18 | Longwood Freshmen - Sophomore Championships | 2016 |
| 65 | 65.80 | Summer DennisMiddle Country | Middle Country '04 | Suffolk County Girls | 2004 |
| 66 | 1:05.83 | Sara MangelsLongwood | Longwood | Section XI State Qualifer Day 1 | 2026 |
| 67 | 65.89 | Erica HowardHalf Hollow Hills East | Half Hollow Hills East '06 | Girls Division Championship Meet | 2005 |
| 68 | 65.90 | Caitlin McLaughlinNorthport | Northport '09 | Girls Division Championship Meet | 2008 |
| 69 | 1:05.91 | Ida ReinigerSouthold | Southold | East End Classic | 2026 |
| 70 | 65.92 | Olivia HallsteinLongwood | Longwood '11 | Girls Division Championship Meet | 2009 |
| 71 | 65.95 | Sarah BellCommack | Commack '11 | Girls Division Championship Meet | 2011 |
| 72 | 1:05.99 | Sara O'BrienEast Hampton | East Hampton '26 | East End Classic | 2026 |
| 73 | 66.00 | Kayla CataldoSachem North | Sachem North '11 | Girls Division Championship Meet | 2011 |
| 74 | 1:06.02 | Jenna TompkinsCommack | Commack '21 | Section XI Girls Division Championships | 2018 |
| 75 | 66.02 | Ashley ClarkeEast Islip | East Islip '06 | Section XI Individual Championships | 2004 |
| 76 | 66.04 | Christy CliftonShoreham-Wading River | Shoreham-Wading River '07 | Section XI Division Championships | 2006 |
| 77 | 66.06 | Shelby TrentiniSachem East | Sachem East '16 | Saint Anthony's Invitational | 2016 |
| 78 | 66.10 | Nikki MosbyLongwood | Longwood '13 | Bellport Invitational | 2012 |
| 79 | 66.16 | Aviana GoodeBay Shore | Bay Shore '16 | Girls Division Championship Meet | 2014 |
| 80 | 66.17 | Meagan HartoughNorthport | Northport '11 | Saint Anthony's Invitational | 2010 |
| 81 | 66.17 | Nikki LaRoccaIslip | Islip '15 | Chris Urban & Brittany Walsh Invitational | 2014 |
| 82 | 1:06.28 | Gabriella MenendezBrentwood | Brentwood '20 | Section XI Girls Division Championships | 2018 |
| 83 | 66.32 | Alanna HollbornEast Islip | East Islip '05 | Section XI Individual Championships | 2004 |
| 84 | 66.34 | Colleen DoyleMount Sinai | Mount Sinai '07 | SA Inv results 2 | |
| 85 | 66.37 | Danielle TorittoSmithtown East | Smithtown East '09 | Girls Division Championship Meet | 2008 |
| 86 | 1:06.37 | Madeline McKillopSayville | Sayville '24 | Section XI State Qualifier | 2024 |
| 87 | 1:06.44 | Savannah KellerNorth Babylon | North Babylon | Section XI State Qualifer Day 2 | 2026 |
| 88 | 1:06.51 | Kelly HughesMt. Sinai | Mt. Sinai | Suffolk 4B County Championships | 2025 |
| 89 | 66.53 | Kianna HawkinsWilliam Floyd | William Floyd '19 | Section XI State Qualifier Championships | 2018 |
| 90 | 66.53 | Mackenzie StikelmanJohn Glenn | John Glenn '22 | 47th Saint Anthony's Invitational | 2018 |
| 91 | 1:06.54 | Paulina GasparisMiller Place | Miller Place '21 | Section XI Girls Division Championships | 2018 |
| 92 | 66.56 | Camille CrossBrentwood | Brentwood '08 | Girls Division Championship Meet | 2008 |
| 93 | 1:06.63 | Kathryn SimonettiEast Islip | East Islip '27 | Section XI State Qualifer | 2025 |
| 94 | 66.66 | Chantal WilliamsHalf Hollow Hills West | Half Hollow Hills West '10 | Section XI Individual Championships | 2010 |
| 95 | 66.66 | Destiny McElroyRiverhead | Riverhead '14 | Girls Division Championship Meet | 2012 |
| 96 | 66.66 | Angela CalabreseSachem East | Sachem East '17 | 46th Saint Anthony's Invitational | 2017 |
| 97 | 66.67 | Mary McGaleySt. John the Baptist | St. John the Baptist '11 | NSCHSAA League Championships | 2011 |
| 98 | 1:06.69 | Lailani DelinoisConnetquot | Connetquot | Suffolk B County Championships | 2026 |
| 99 | 66.71 | Meredith HaberfieldSt. John the Baptist | St. John the Baptist '19 | NSCHSAA League Championships | 2018 |
| 100 | 66.75 | Jaden CatalinaSayville | Sayville '21 | Section XI State Qualifier Championships | 2018 |
