| 1 | 4:19.01 | Maggie McCormickBay Shore | Bay Shore '26 | Section XI State Qualifer Day 2 | 2026 |
| 2 | 4:21.66 | Maddie LaezzaEastport-South Manor | Eastport-South Manor '27 | Section XI State Qualifer Day 2 | 2026 |
| 3 | 4:25.76 | Zariel MacchiaWilliam Floyd | William Floyd '25 | Section XI State Qualifer | 2025 |
| 4 | 4:26.54 | Kelsey MargeyHarborfields | Harborfields '12 | Saint Anthony's Invitational | 2011 |
| 5 | 4:27.52 | Sophia McInnesBayport-Blue Point | Bayport-Blue Point | Section XI State Qualifer | 2025 |
| 6 | 4:28.54 | Mary Liz McCurdyBay Shore | Bay Shore '05 | Section XI Individual Championships | 2004 |
| 7 | 4:29.16 | Tiana GuevaraMiller Place | Miller Place '14 | Stony Brook University - Wolfie Invitational | 2018 |
| 8 | 4:30.00 | Laina FriedmannSmithtown West | Smithtown West | Section XI State Qualifier | 2024 |
| 9 | 4:30.11 | Katherine LeeShoreham-Wading River | Shoreham-Wading River '18 | Saint Anthony's Invitational | 2016 |
| 10 | 4:31.06 | Laura CummingsBay Shore | Bay Shore '05 | Section XI Girls Team Championships | 2004 |
| 11 | 4:31.42 | Mary Kate AnselminWard Melville | Ward Melville '11 | Girls Division Championship Meet | 2011 |
| 12 | 4:31.49 | Brittany SheffeyBellport | Bellport '07 | Section XI Girls Team Championships | 2004 |
| 13 | 4:31.63 | Mary Kate AnselminiWard Melville | Ward Melville '11 | Girls Division Championship Meet | 2009 |
| 14 | 4:31.67 | Alexandra DeCiccoSachem East | Sachem East '16 | Saint Anthony's Invitational | 2016 |
| 15 | 4:32.03 | Allison KiefferWest Islip | West Islip '05 | Section XI Girls Team Championships | 2004 |
| 16 | 4:32.81 | Jaclyn MarshallKings Park | Kings Park '08 | Section XI Individual Championships | 2008 |
| 17 | 4:34.28 | Rachel PaulSachem East | Sachem East '12 | Section XI Individual Championships | 2011 |
| 18 | 4:34.77 | Sayla FivesHarborfields | Harborfields '27 | Section XI State Qualifer Day 2 | 2026 |
| 19 | 4:34.97 | Kate PouderMiller Place | Miller Place '11 | Stony Brook University - Wolfie Invitational | 2016 |
| 20 | 4:34.98 | Kristy LongmanSayville | Sayville '07 | Section XI Division Championships | 2006 |
| 21 | 4:35.16 | Lexie ColeComsewogue | Comsewogue '27 | Massapequa Last Chance Invitational | 2025 |
| 22 | 4:35.43 | Christina MelianStony Brook | Stony Brook | Stony Brook University - Wolfie Invitational | 2014 |
| 23 | 4:36.22 | Ellen DoughertyRiverhead | Riverhead '05 | Section XI Girls Team Championships | 2004 |
| 24 | 4:36.48 | Callie HoganBay Shore | Bay Shore '07 | Section XI Division Championships | 2006 |
| 25 | 4:36.90 | Christine EisenberHauppauge | Hauppauge '13 | Stony Brook University - Wolfie Invitational | 2016 |
| 26 | 4:37.45 | Anne CareySt. John the Baptist | St. John the Baptist '11 | NSCHSAA League Championships | 2011 |
| 27 | 4:37.80 | Olivia DiGaetanoConnetquot | Connetquot '26 | North Babylon Invitational | 2026 |
| 28 | 4:37.88 | Brigid BrennanNorthport | Northport '14 | Girls Division Championship Meet | 2011 |
| 29 | 4:38.02 | Samantha RuttWard Melville | Ward Melville '18 | Section XI State Qualifier Championships | 2018 |
| 30 | 4:38.07 | Sarah ConnellyMount Sinai | Mount Sinai '20 | Section XI State Qualifier Championships | 2018 |
| 31 | 4:38.14 | Suejin AhnWard Melville | Ward Melville '08 | Section XI Division Championships | 2006 |
| 32 | 4:38.23 | Sarah McCurdyBay Shore | Bay Shore '08 | Girls Division Championship Meet | 2008 |
| 33 | 4:38.28 | Ashlee RommeneySachem East | Sachem East '14 | Girls Division Championship Meet | 2011 |
| 34 | 4:38.84 | Jamie GrossmanHarborfields | Harborfields '15 | Section XI Individual Championships | 2014 |
| 35 | 4:38.96 | Mary ConnorStony Brook | Stony Brook | Stony Brook University Track & Field Invitati | 2012 |
| 36 | 4:38.97 | Erin HaysShoreham-Wading River | Shoreham-Wading River '07 | New York State Track & Field Championships | 2006 |
| 37 | 4:39.29 | Olivia RitchieStony Brook | Stony Brook | Stony Brook University - Wolfie Invitational | 2014 |
| 38 | 4:40.40 | Ciara MurphySachem East | Sachem East '16 | Stony Brook University - Wolfie Invitational | 2018 |
| 39 | 4:40.50 | Kaitlyn OhrtmanShoreham-Wading River | Shoreham-Wading River '16 | Saint Anthony's Invitational | 2015 |
| 40 | 4:40.51 | Megan ReillyDeer Park | Deer Park '11 | Section XI Individual Championships | 2011 |
| 41 | 4:40.52 | Olivia CivardiBay Shore | Bay Shore '09 | Girls Division Championship Meet | 2009 |
| 42 | 4:40.71 | Erin NevilleCommack | Commack '14 | Section XI Individual Championships | 2011 |
| 43 | 4:41.16 | Caroline O'HeaWard Melville | Ward Melville '12 | Girls Division Championship Meet | 2011 |
| 44 | 4:41.24 | Lauren FontanaSt. Anthony's | St. Anthony's '12 | NSCHSAA League Championships | 2011 |
| 45 | 4:41.41 | Anna GansrowEastport-South Manor | Eastport-South Manor '24 | Massapequa Chief Invitational - Under The Lights | 2024 |
| 46 | 4:41.69 | Margaret TuthillMercy | Mercy '16 | Saint Anthony's Invitational | 2015 |
| 47 | 4:41.70 | Taylor McClayEastport-South Manor | Eastport-South Manor '17 | Longwood Freshmen - Sophomore Championships | 2015 |
| 48 | 4:41.95 | Payton Capes-DavisShoreham-Wading River | Shoreham-Wading River '17 | 46th Saint Anthony's Invitational | 2017 |
| 49 | 4:42.17 | Christine HaganKings Park | Kings Park '11 | Saint Anthony's Invitational | 2009 |
| 50 | 4:42.18 | Melanie NotarstefanoSachem East | Sachem East '12 | Section XI Individual Championships | 2010 |
| 51 | 4:42.18 | Shanna HeaneyHampton Bays | Hampton Bays '13 | Stony Brook University - Wolfie Invitational | 2016 |
| 52 | 4:42.63 | Mia WickardNorthport | Northport '27 | St. Anthony's Invitational | 2024 |
| 53 | 4:42.81 | Nicole AbbondandeloHuntington | Huntington '18 | Massapequa Under the Lights | 2018 |
| 54 | 4:42.99 | Sarah HardieJohn Glenn | John Glenn '14 | Girls Division Championship Meet | 2014 |
| 55 | 4:43.14 | Kelsey AmarosaSmithtown East | Smithtown East '12 | Girls Division Championship Meet | 2012 |
| 56 | 4:44.10 | Shannon McDonnellShoreham-Wading River | Shoreham-Wading River '12 | Section XI Individual Championships | 2011 |
| 57 | 4:44.20 | Nicole GarciaShoreham-Wading River | Shoreham-Wading River '20 | Stony Brook Snowflake Classic | 2023 |
| 58 | 4:44.60 | Valerie RomeroSachem East | Sachem East '16 | Saint Anthony's Invitational | 2016 |
| 59 | 4:44.75 | Jessica HampsonSmithtown | Smithtown '06 | Section XI Girls Team Championships | 2004 |
| 60 | 4:44.79 | Kerry GayeHarborfields | Harborfields '15 | Stony Brook University - Wolfie Invitational | 2018 |
| 61 | 4:44.81 | Talia GuevaraMiller Place | Miller Place '14 | Stony Brook University - Wolfie Invitational | 2015 |
| 62 | 4:44.86 | Catherine FarrellSmithtown East | Smithtown East '19 | Section XI State Qualifier Championships | 2018 |
| 63 | 4:45.11 | Kaitlyn ChandrikaMount Sinai | Mount Sinai '21 | Joe Brandi Relays | 2018 |
| 64 | 4:45.35 | Katherine SkinnerRiverhead | Riverhead '10 | Section XI Individual Championships | 2009 |
| 65 | 4:45.38 | Sofia CondronJohn Glenn | John Glenn '22 | Don Bohlinger Invitational | 2019 |
| 66 | 4:45.40 | Camryn GoodmanSachem East | Sachem East | Section XI State Qualifier | 2024 |
| 67 | 4:45.50 | Annie KeownStony Brook | Stony Brook | Stony Brook University Track & Field Invitati | 2012 |
| 68 | 4:45.53 | Melissa MeroneSachem East | Sachem East '20 | 47th Saint Anthony's Invitational | 2018 |
| 69 | 4:45.59 | Fiona KingNorthport | Northport '29 | Section XI State Qualifer | 2025 |
| 70 | 4:45.60 | Jessica BallWest Islip | West Islip '13 | Girls' Suffolk Coaches Meet | 2012 |
| 71 | 4:45.94 | Jessica ScheriffNorth Babylon | North Babylon '14 | Suffolk Coaches Girls Track & Field Invitatio | 2014 |
| 72 | 4:45.97 | Kate McCormackSt. John the Baptist | St. John the Baptist '15 | Stony Brook University - Wolfie Invitational | 2016 |
| 73 | 4:45.97 | Finnley WickardNorthport | Northport | St. Anthony's Invitational | 2024 |
| 74 | 4:46.08 | Maria SmithShoreham-Wading River | Shoreham-Wading River '17 | 46th Saint Anthony's Invitational | 2017 |
| 75 | 4:46.08 | Deanna SchmittBayport-Blue Point | Bayport-Blue Point '06 | Girls Division Championship Meet | 2005 |
| 76 | 4:46.25 | Leah NowakowskiSachem North | Sachem North '30 | Section XI State Qualifer Day 2 | 2026 |
| 77 | 4:46.40 | Kathleen NaeherKings Park | Kings Park '13 | Bellport Invitational | 2012 |
| 78 | 4:46.50 | Laura GreenSachem East | Sachem East '08 | Girls Division Championship Meet | 2005 |
| 79 | 4:46.53 | Lindsey DodenhoffSachem East | Sachem East '19 | 46th Saint Anthony's Invitational | 2017 |
| 80 | 4:46.81 | Jane TuckerNorthport | Northport '29 | St. Anthony's Invitational | 2024 |
| 81 | 4:46.83 | Christine JohnstonLongwood | Longwood '08 | Girls Division Championship Meet | 2005 |
| 82 | 4:46.83 | Kelly LavanSachem North | Sachem North '13 | Girls Division Championship Meet | 2012 |
| 83 | 4:46.85 | Victoria IngramSmithtown West | Smithtown West '14 | Smithtown Invitational | 2013 |
| 84 | 4:47.02 | Laura GreeneSachem East | Sachem East '08 | Section XI Division Championships | 2006 |
| 85 | 4:47.03 | Mullane BaumillerSayville | Sayville '24 | North Babylon Invitational | 2024 |
| 86 | 4:47.11 | Suzie PetrykHuntington | Huntington '15 | Bob Pratt Memorial Track & Field Invitational | 2015 |
| 87 | 4:47.18 | Delaney WorthSt. Anthony's | St. Anthony's '14 | NSCHSAA League Championships | 2012 |
| 88 | 4:47.23 | Christine EisenbergHauppauge | Hauppauge '13 | Longwood Freshmen - Sophomore Championships | 2011 |
| 89 | 4:47.29 | Jennifer JohnstonLongwood | Longwood '10 | Girls Division Championship Meet | 2009 |
| 90 | 4:47.36 | Donna CheungConnetquot | Connetquot '07 | Girls SQ Results 2B | 2006 |
| 91 | 4:47.41 | Erin EndresSt. John the Baptist | St. John the Baptist '16 | NSCHSAA League Championships | 2014 |
| 92 | 4:47.44 | Tara HauffWest Babylon | West Babylon '18 | Stony Brook Snowflake Classic | 2022 |
| 93 | 4:47.64 | Deirdre ConnorSmithtown East | Smithtown East '14 | Girls Division Championship Meet | 2012 |
| 94 | 4:47.74 | Ava CaponeDeer Park | Deer Park '23 | The 18th Annual Bulldog Invite at Hewlett High School | 2022 |
| 95 | 4:48.04 | Sarah NewmanSayville | Sayville '22 | The Don Bohlinger Invitational | 2022 |
| 96 | 4:48.06 | Saige SmithNorth Babylon | North Babylon '27 | Suffolk B County Championships | 2026 |
| 97 | 4:48.11 | Kathryn AllardMiller Place | Miller Place '06 | Section XI Division Championships | 2006 |
| 98 | 4:48.19 | Paige KeeferWest Babylon | West Babylon '17 | 46th Saint Anthony's Invitational | 2017 |
| 99 | 4:48.23 | Amy IrvingConnetquot | Connetquot '13 | Smithtown Invitational | 2013 |
| 100 | 4:48.56 | Janie TurekMount Sinai | Mount Sinai '11 | Girls Division Championship Meet | 2009 |
