| 1 | 52.85 | Joseph PaytonLongwood | Longwood '11 | Section XI Individual Championships | 2011 |
| 2 | 53.14 | Infinite TuckerHuntington | Huntington '16 | Section XI State Qualifier Championships | 2015 |
| 3 | 53.20 | Trevor GuerreraSachem East | Sachem East '14 | Section XI Individual Championships | 2014 |
| 4 | 53.35 | Kadesh RobertsBay Shore | Bay Shore '12 | Section XI Individual Championships | 2011 |
| 5 | 53.61 | Tobias NelsonBrentwood | Brentwood '14 | Section XI Individual Championships | 2014 |
| 6 | 53.64 | Sam ChimezieHalf Hollow Hills East | Half Hollow Hills East '15 | Section XI State Qualifier Championships | 2015 |
| 7 | 53.67 | Ramon SosaBrentwood | Brentwood '04 | Section XI Individual Championships | 2004 |
| 8 | 53.86 | Kaden ReidLongwood | Longwood | Section XI State Qualifer | 2025 |
| 9 | 53.91 | Mark CastillettiBayport-Blue Point | Bayport-Blue Point '10 | Section XI Individual Championships | 2010 |
| 10 | 53.92 | Utsav DeshpandeSachem East | Sachem East '15 | Section XI State Qualifier Championships | 2015 |
| 11 | 53.93 | Matt TommasinoBayport-Blue Point | Bayport-Blue Point '04 | Section XI Individual Championships | 2004 |
| 12 | 53.97 | Rashim GainesAmityville | Amityville '09 | Section XI Individual Championships | 2009 |
| 13 | 54.33 | Brian GilmartinCentereach | Centereach '06 | Boys State Meet Results | 2006 |
| 14 | 54.37 | Dwayne MorganRiverhead | Riverhead | Section XI State Qualifer Day 2 | 2026 |
| 15 | 54.40 | Jaheim DotsonLongwood | Longwood '19 | Section XI State Qualifier Championships | 2018 |
| 16 | 54.42 | Terry MartinStony Brook | Stony Brook | Stony Brook University Track & Field Invitati | 2012 |
| 17 | 54.62 | Jordan PeckNorth Babylon | North Babylon | Port Washington Invitational | 2025 |
| 18 | 54.69 | Spencer PaytonLongwood | Longwood '16 | Boys Division Championship Meet | 2015 |
| 19 | 54.74 | John StallworthConnetquot | Connetquot '13 | Section XI Individual Championships | 2013 |
| 20 | 54.81 | Fernando SanchezSt. John the Baptist | St. John the Baptist '21 | NSCHSAA Varsity Spring Track Track & Field Championship | 2021 |
| 21 | 54.98 | Johnathan SmithHuntington | Huntington '19 | Section XI Boys Division Championships | 2018 |
| 22 | 55.00 | Rob SchenkeKings Park | Kings Park '11 | Section XI Individual Championships | 2011 |
| 23 | 55.02 | Sancho BarrettAmityville | Amityville '11 | Boys Division Championship Meet | 2010 |
| 24 | 55.09 | Gueniel ElyseeHuntington | Huntington | Section XI State Qualifer | 2025 |
| 25 | 55.12 | Nick BeglaneHauppauge | Hauppauge '16 | Section XI State Qualifier Championships | 2015 |
| 26 | 55.16 | Sean QuinnNorthport | Northport '06 | Boys State Meet Results | 2006 |
| 27 | 55.21 | Joseph FoderaJohn Glenn | John Glenn '12 | Saint Anthony's Invitational | 2012 |
| 28 | 55.23 | Jared NilssonWesthampton Beach | Westhampton Beach '08 | Boys Division Championship Meet | 2008 |
| 29 | 55.26 | Matt FerrerConnetquot | Connetquot '15 | Section XI State Qualifier Championships | 2015 |
| 30 | 55.28 | Jeff GregoryWest Islip | West Islip '09 | Section XI Individual Championships | 2009 |
| 31 | 55.31 | Colin O'ConnorWest Islip | West Islip '12 | Boys Division Championship Meet | 2012 |
| 32 | 55.32 | Dominic MorganWest Islip | West Islip '12 | Boys Division Championship Meet | 2012 |
| 33 | 55.38 | Isaac MarshallLongwood | Longwood '09 | Section XI Individual Championships | 2009 |
| 34 | 55.44 | Michael LinbrunnerLongwood | Longwood '16 | Section XI State Qualifier Championships | 2015 |
| 35 | 55.47 | Austin ArchibaldLongwood | Longwood '07 | Boys Division Championships 07b | |
| 36 | 55.47 | Jose GenaoComsewogue | Comsewogue '04 | Section XI Individual Championships | 2004 |
| 37 | 55.49 | Daniel GrossPort Jefferson | Port Jefferson '14 | Section XI Individual Championships | 2014 |
| 38 | 55.51 | Travon DuncanAmityville | Amityville '15 | Section XI State Qualifier Championships | 2015 |
| 39 | 55.59 | Daniel PimentaHampton Bays | Hampton Bays '28 | Section XI State Qualifer Day 2 | 2026 |
| 40 | 55.65 | Vincent ZietsmanComsewogue | Comsewogue '09 | Section XI Individual Championships | 2009 |
| 41 | 55.67 | Ryan BuddRiverhead | Riverhead '10 | Boys Division Championship Meet | 2010 |
| 42 | 55.72 | Kevin MartinezDeer Park | Deer Park '10 | Section XI Individual Championships | 2010 |
| 43 | 55.74 | Kyler PizzoBellport | Bellport '19 | Section XI State Qualifier Championships | 2018 |
| 44 | 55.88 | Devin SullivanNorthport | Northport '14 | Section XI Individual Championships | 2014 |
| 45 | 55.89 | William WitrockPort Jefferson | Port Jefferson '16 | 68th Suffolk County Relays | 2016 |
| 46 | 55.95 | Jake ParrettHauppauge | Hauppauge '26 | Section XI State Qualifer Day 2 | 2026 |
| 47 | 55.99 | Ian MorganAmityville | Amityville '04 | Saint Anthony's Invitational | 2004 |
| 48 | 56.03 | Travis ColonComsewogue | Comsewogue '19 | North Shore Invitational | 2018 |
| 49 | 56.10 | Nikolai LulewichHuntington | Huntington | Section XI State Qualifier | 2024 |
| 50 | 56.18 | Exayvian CrowellHuntington | Huntington '16 | Boys Division Championship Meet | 2015 |
| 51 | 56.21 | Quincy CheryHuntington | Huntington '22 | Long Island Meet of Champions at St. Anthonys | 2022 |
| 52 | 56.25 | Christopher QuillaSmithtown West | Smithtown West '16 | Stony Brook University - Wolfie Invitational | 2017 |
| 53 | 56.25 | Sviatoslav ZalizniakPort Jefferson | Port Jefferson '26 | Suffolk D County Championships | 2026 |
| 54 | 56.30 | Azeem BoyceSt. John the Baptist | St. John the Baptist '10 | League Championships | 2010 |
| 55 | 56.36 | Cody AmengualWest Babylon | West Babylon '10 | Boys Division Championship Meet | 2010 |
| 56 | 56.40 | Anthony GirolamoNorthport | Northport '08 | Boys Division Championship Meet | 2008 |
| 57 | 56.42 | Mario MayenCenter Moriches | Center Moriches '12 | Westhampton Beach Invitational | 2012 |
| 58 | 56.43 | Michael ThompsonStony Brook | Stony Brook | Stony Brook University - Wolfie Invitational | 2018 |
| 59 | 56.44 | Rolando BanksWilliam Floyd | William Floyd '19 | Section XI State Qualifier Championships | 2018 |
| 60 | 56.46 | Joe MicheelsSt. John the Baptist | St. John the Baptist '10 | Saint Anthony's Invitational | 2010 |
| 61 | 56.50 | Matt LaffertyEastport-South Manor | Eastport-South Manor '14 | Section XI Individual Championships | 2014 |
| 62 | 56.51 | DJ BrownCopiague | Copiague '13 | Section XI Individual Championships | 2013 |
| 63 | 56.51 | Charles WhitcombSt. Anthony's | St. Anthony's '21 | NSCHSAA Varsity Spring Track Track & Field Championship | 2021 |
| 64 | 56.51 | James ReillySayville | Sayville '15 | Suffolk Coaches Meet | 2015 |
| 65 | 56.59 | Daniel PaolellaMt. Sinai | Mt. Sinai | East End Classic | 2026 |
| 66 | 56.62 | Shane CruzLongwood | Longwood '11 | Saint Anthony's Invitational | 2010 |
| 67 | 56.63 | Danny WrorbelLongwood | Longwood '07 | Boys Division Championships 07b | |
| 68 | 56.64 | Jack FloodBayport-Blue Point | Bayport-Blue Point '13 | Boys Division Championship Meet | 2013 |
| 69 | 56.66 | Christopher QuillStony Brook | Stony Brook | Stony Brook University Season Opener | 2017 |
| 70 | 56.67 | Joe MillsBay Shore | Bay Shore '04 | Section XI Boys Team Championships | 2004 |
| 71 | 56.71 | Brian JohnsonAmityville | Amityville '09 | Town of Babylon Championships | 2009 |
| 72 | 56.74 | Bailey ImboBayport-Blue Point | Bayport-Blue Point '13 | Boys Division Championship Meet | 2013 |
| 73 | 56.74 | Jefferson DuclairBrentwood | Brentwood | Section XI State Qualifier | 2024 |
| 74 | 56.75 | Tommy WheelerRocky Point | Rocky Point '12 | Boys Division Championship Meet | 2012 |
| 75 | 56.80 | Robert MaloneSt. Anthony's | St. Anthony's '06 | NSCHSAA Spring Track & Field League Championships | 2006 |
| 76 | 56.81 | Connor HattonSt. John the Baptist | St. John the Baptist '15 | Saint Anthony's Invitational | 2015 |
| 77 | 56.82 | Keenan WeavingHalf Hollow Hills West | Half Hollow Hills West '08 | Boys Division Championship Meet | 2008 |
| 78 | 56.82 | Calvin ManchenkoHalf Hollow Hills East | Half Hollow Hills East '13 | Boys Division Championship Meet | 2013 |
| 79 | 56.82 | Arman HezarkhaniComsewogue | Comsewogue '15 | Section XI Individual Championships | 2014 |
| 80 | 56.83 | Emile BarnettJohn Glenn | John Glenn '07 | Boys Division Championships 07b | |
| 81 | 56.84 | Evan MonaghanPort Jefferson | Port Jefferson | Section XI State Qualifer | 2025 |
| 82 | 56.89 | Mack BrandonSouthampton | Southampton '09 | Section XI Individual Championships | 2009 |
| 83 | 56.91 | Michael LoiaconoWard Melville | Ward Melville '09 | Section XI Individual Championships | 2009 |
| 84 | 56.96 | Kareem RobertsBay Shore | Bay Shore '13 | Boys Division Championship Meet | 2012 |
| 85 | 56.98 | Kaashief MorganAmityville | Amityville '14 | Saint Anthony's Invitational | 2014 |
| 86 | 57.00 | Rod AlzmannWest Islip | West Islip '07 | Suffolk Coaches Meet | 2007 |
| 87 | 57.00 | Walter PenateLongwood | Longwood '13 | Boys Division Championship Meet | 2012 |
| 88 | 57.05 | Ethan WidingConnetquot | Connetquot | Suffolk 1A County Championships | 2025 |
| 89 | 57.08 | Benjamin NeimanPort Jefferson | Port Jefferson '12 | Boys Division Championship Meet | 2012 |
| 90 | 57.08 | Xavier CadwellBrentwood | Brentwood '15 | Boys Division Championship Meet | 2015 |
| 91 | 57.08 | Renaco BrownBrentwood | Brentwood '06 | Boys SQ Results 2B | 2006 |
| 92 | 57.09 | William MiltenbergJohn Glenn | John Glenn '06 | Boys SQ Results 2B | 2006 |
| 93 | 57.15 | Jaden MitchellLongwood | Longwood | Section XI State Qualifier | 2024 |
| 94 | 57.16 | Jamal MarshallLongwood | Longwood '13 | Boys Division Championship Meet | 2013 |
| 95 | 57.17 | Thomas GilmartinMiddle Country | Middle Country '08 | Boys Division Championship Meet | 2008 |
| 96 | 57.18 | Justin StevensHuntington | Huntington '20 | Section XI Boys Division Championships | 2018 |
| 97 | 57.20 | Donovan BosticNorth Babylon | North Babylon '06 | Saint Anthony’s Invitational | |
| 98 | 57.20 | Jason DemidowShoreham-Wading River | Shoreham-Wading River '09 | Section XI Individual Championships | 2009 |
| 99 | 57.20 | George ErazoNorth Babylon | North Babylon '10 | St. Joseph's College Track & Field Invitational | 2015 |
| 100 | 57.28 | Aaron McFaddenCopiague | Copiague '15 | Derrick Adkins Holiday Classic | 2015 |
