| 1 | 11.58 | Austin MaSyosset | Syosset '26 | Division 1A Championship | 2026 |
| 2 | 11.7 | Nickesha BrownHempstead | Hempstead '03 | Class A County | 2002 |
| 3 | 11.8 | Maxine MoodieHempstead | Hempstead '07 | State Qualifier | 2007 |
| 4 | 11.9 | Joshua HeironymusRoosevelt | Roosevelt | Greenand Gold Results | |
| 5 | 11.94 | Beyona MonroeRoosevelt | Roosevelt '21 | Section VIII Division 3A Championships | 2018 |
| 6 | 11.96 | Ashley FultonElmont Memorial | Elmont Memorial '24 | Section 8 Class AA | 2024 |
| 7 | 12.0 | Jasmine BlockerManhasset | Manhasset '10 | State Qualifier | 2008 |
| 8 | 12.0 | Heidi PaulUniondale | Uniondale '07 | State Qualifier | 2007 |
| 9 | 12.0 | Christie VerdierBaldwin | Baldwin '08 | Division 1B Championships | 2006 |
| 10 | 12.00 | Nickesha WilliamsUniondale | Uniondale '05 | Saint Anthony's Invitational | 2005 |
| 11 | 12.0 | Saade MitchellJericho | Jericho '04 | Class AA Counties | 2004 |
| 12 | 12.0 | Samantha EdwardsFloral Park Memorial | Floral Park Memorial '08 | Class AA County | 2008 |
| 13 | 12.01 | Sariah DorescaBaldwin | Baldwin | Section 8 AAA County Championship | 2025 |
| 14 | 12.02 | Esmia ThomasRoosevelt | Roosevelt '26 | Division 2B Championship | 2026 |
| 15 | 12.05 | Imani GrayElmont | Elmont '18 | 47th Saint Anthony's Invitational | 2018 |
| 16 | 12.1 | Ricki VelottiHewlett | Hewlett '04 | Class AA Counties | 2004 |
| 17 | 12.1 | Deidra BryantBaldwin | Baldwin '08 | State Qualifier | 2008 |
| 18 | 12.13 | Victoria DanielSouth Side | South Side | Section 8 Class AA | 2024 |
| 19 | 12.15 | Valencia HannonElmont | Elmont '12 | Saint Anthony's Invitational | 2010 |
| 20 | 12.17 | Kelys WalkerBaldwin | Baldwin | Section 8 AAA County Championship | 2025 |
| 21 | 12.19 | Mary Kate KennySacred Heart | Sacred Heart '15 | Stony Brook University - Wolfie Invitational | 2018 |
| 22 | 12.2 | Ashley McCarthyElmont | Elmont '11 | Division 2A Championships | |
| 23 | 12.20 | Chibugo ObichereValley Stream South | Valley Stream South '19 | Section VIII County Class 1 A - Girls | |
| 24 | 12.2 | Rebecca KaplanOyster Bay | Oyster Bay '08 | Division 4B Championships | 2006 |
| 25 | 12.2 | Katisha CunninghamFreeport | Freeport '02 | Class A County | 2002 |
| 26 | 12.2 | Tenile BernardValley Stream Central | Valley Stream Central '03 | State Qualifier | 2003 |
| 27 | 12.2 | Yoanne IsmaelValley Stream Central | Valley Stream Central '05 | Division IIA | 2005 |
| 28 | 12.2 | Jonathan RocheSewanhaka | Sewanhaka | Greenand Gold Results | |
| 29 | 12.24 | Julissa AbrahamsLong Island Lutheran | Long Island Lutheran | North Shore Invitational | 2025 |
| 30 | 12.26 | Fallon WilksHempstead | Hempstead '06 | Class AAA | 2006 |
| 31 | 12.29 | Kennedy KerrLI Lutheran | LI Lutheran '16 | New York State Track & Field Championships | 2014 |
| 32 | 12.3 | Taurean SpoonerHempstead | Hempstead '03 | Class A County | 2002 |
| 33 | 12.3 | Yleana RomanH. Frank Carey | H. Frank Carey '02 | Division IIIA | 2002 |
| 34 | 12.3 | Ester ReidUniondale | Uniondale '03 | Class A Counties | 2003 |
| 35 | 12.3 | Janna KauferLynbrook | Lynbrook '08 | Frosh/Soph Championships | 2005 |
| 36 | 12.30 | Brooke LinHerricks | Herricks '26 | Herricks Invitational | 2026 |
| 37 | 12.35 | Danielle LawrenceSanford H. Calhoun | Sanford H. Calhoun | Section 8 Class AA | 2024 |
| 38 | 12.35 | Destiny Chan-HescottHempstead | Hempstead '28 | Division 1A Championship | 2026 |
| 39 | 12.36 | Logan DaleyHoly Trinity | Holy Trinity '24 | NSCHSAA Varsity Spring Track Track & Field Championship | 2021 |
| 40 | 12.37 | E''Shone CofieldGlen Cove | Glen Cove '19 | Section VIII Division 3A Championships | 2018 |
| 41 | 12.38 | Shaday LawrenceRoosevelt | Roosevelt '16 | Knight Time Invitational | 2016 |
| 42 | 12.39 | Kiyah OwensManhasset | Manhasset '16 | Don Scott Memorial Relays | 2016 |
| 43 | 12.39 | Savannah StephensonBaldwin | Baldwin '27 | Section 8 State Qualifier - Day 2 | 2026 |
| 44 | 12.40 | Odrine BelotKellenberg | Kellenberg '12 | NSCHSAA League Championships | 2012 |
| 45 | 12.4 | Ashley BryantFreeport | Freeport '07 | Conference IA | 2007 |
| 46 | 12.4 | Nwamaka OkobiFreeport | Freeport '07 | Nassau Coaches Meet | 2007 |
| 47 | 12.4 | Alexis DeFalcoMassapequa | Massapequa '08 | Frosh/Soph Championships | 2005 |
| 48 | 12.4 | Cherrelle KingElmont | Elmont '10 | Division 2A Championships | |
| 49 | 12.4 | Jennifer HamannJericho | Jericho '02 | Class B County | 2002 |
| 50 | 12.4 | Rickita JenningsMalverne | Malverne '06 | Division 4B Championships | 2006 |
| 51 | 12.4 | Nikeisha WilliamsUniondale | Uniondale '05 | State Qualifier | 2004 |
| 52 | 12.4 | Nakeitta HughesElmont | Elmont '08 | Division IIA | 2005 |
| 53 | 12.4 | Sabrina BudaiHempstead | Hempstead '05 | Division IA Championships | 2005 |
| 54 | 12.4 | Sharifah RobertsonSouth Side | South Side '09 | Class AA County | 2007 |
| 55 | 12.41 | Skyla HuntMalverne | Malverne '26 | Section 8 A County Championship | 2026 |
| 56 | 12.42 | Gianna McGowanIsland Trees | Island Trees '21 | Section VIII County Class 1 A - Girls | |
| 57 | 12.44 | ChrisAnn RoyalSewanhaka | Sewanhaka '21 | Section VIII Division 3A Championships | 2018 |
| 58 | 12.44 | Shaday LawerenceRoosevelt | Roosevelt '16 | Section VIII State Qualifier Meet | 2015 |
| 59 | 12.45 | Natalie LongobuccoGeneral Douglas MacArthur | General Douglas MacArthur | North Shore Invitational | 2024 |
| 60 | 12.45 | Lenora JonesVal Stream South | Val Stream South '27 | Section 8 A County Championships | 2025 |
| 61 | 12.46 | Kathryn KellySouth Side | South Side '06 | Stony Brook University - Wolfie Invitational | 2018 |
| 62 | 12.48 | Cameryn MillerFreeport | Freeport '16 | Section VIII Class 3A County Championships | 2015 |
| 63 | 12.50 | Ashe DavisRoosevelt | Roosevelt '14 | New York State Track & Field Championships | 2014 |
| 64 | 12.50 | Victoria ST JohnHoly Trinity | Holy Trinity '16 | Post Easter Classic | 2016 |
| 65 | 12.5 | Charrelle StatonFreeport | Freeport '05 | Mid Island Invitational | 2004 |
| 66 | 12.5 | Emily HepworthGarden City | Garden City '07 | Class AA County | 2007 |
| 67 | 12.5 | Rebecca GoldsteinHerricks | Herricks '03 | Division IIA | 2002 |
| 68 | 12.5 | Angela DavisRoslyn | Roslyn '03 | State Qualifier | 2003 |
| 69 | 12.5 | Sharisse MoodieNew Hyde Park | New Hyde Park '08 | Class AA County | 2008 |
| 70 | 12.5 | Toni-Ann LawrenceElmont | Elmont '09 | Division 2A Championships | 2006 |
| 71 | 12.50 | Harper LolloKellenberg | Kellenberg '27 | Herricks Invitational | 2026 |
| 72 | 12.51 | Olivia MillerValley Stream Central | Valley Stream Central '22 | Nassau Coaches Track & Field Invitational | 2018 |
| 73 | 12.52 | Noveka McKayHempstead | Hempstead '12 | Girls' Suffolk Coaches Meet | 2012 |
| 74 | 12.52 | Niasia HardingHempstead | Hempstead '16 | Section VIII Class 3A County Championships | 2015 |
| 75 | 12.53 | Katherine CavanaughKellenberg | Kellenberg '12 | NSCHSAA League Championships | 2012 |
| 76 | 12.53 | Kendra GordonWestbury | Westbury '27 | Section 8 State Qualifier - Day 2 | 2026 |
| 77 | 12.55 | Maya CherubinSewanhaka | Sewanhaka | Section 8 State Qualifier | 2024 |
| 78 | 12.55 | Grace MummendeyH. Frank Carey | H. Frank Carey '29 | Section 8 AA County Championship | 2026 |
| 79 | 12.58 | Samantha FriedmanOceanside | Oceanside | Blue and White Invitational | 2025 |
| 80 | 12.58 | Yashima MitchellUniondale | Uniondale | Section VIII Championships Division 1A | 2022 |
| 81 | 12.59 | Velma MorantHempstead | Hempstead '09 | Saint Anthony's Invitational | 2009 |
| 82 | 12.59 | Leanne RichardsonFloral Park Memorial | Floral Park Memorial '25 | North Shore Invitational | 2025 |
| 83 | 12.6 | Lauren GrayCarle Place | Carle Place '10 | State Qualifier | 2008 |
| 84 | 12.6 | Rene CousinsHempstead | Hempstead '07 | Division IA Championships | 2005 |
| 85 | 12.6 | Janel MonahWestbury | Westbury '07 | Class AA County | 2007 |
| 86 | 12.60 | Kristin WenthenKellenberg | Kellenberg '08 | NSCHSAA League Championships | 2008 |
| 87 | 12.60 | Alexandria YarbroughFreeport | Freeport '20 | Section VIII Division 1A Championships | 2018 |
| 88 | 12.60 | Jazmyn DuartesWantagh | Wantagh '15 | Hewlett Bulldog Invitational | 2015 |
| 89 | 12.60 | Faith WilliamsFarmingdale | Farmingdale | Section VIII County Championships Class AAA | 2023 |
| 90 | 12.6 | Erin GarveyFarmingdale | Farmingdale '07 | Conference IA | 2007 |
| 91 | 12.6 | Joanna CohenRoslyn | Roslyn '02 | Class B County | 2002 |
| 92 | 12.6 | Nicole MattisFreeport | Freeport '03 | Bob Beer Invitational | 2003 |
| 93 | 12.6 | Raki LavonGreat Neck North | Great Neck North '03 | Division IIIA | 2002 |
| 94 | 12.6 | Tahari BellamyWestbury | Westbury '05 | Class B County | 2002 |
| 95 | 12.6 | Kathleen KobbeLynbrook | Lynbrook '06 | Division 3A Championships | 2006 |
| 96 | 12.6 | Shyvanne DelvaValley Stream Central | Valley Stream Central '08 | Division 2A Championships | 2006 |
| 97 | 12.6 | Courtney MaitlandRoslyn | Roslyn '08 | Division 3A Championships | 2006 |
| 98 | 12.6 | Brandon BarnesWest Hempstead | West Hempstead | Greenand Gold Results | |
| 99 | 12.6 | Ashley BowmanNew Hyde Park | New Hyde Park '09 | 2009 Nassau Coaches Invitational - Girls | |
| 100 | 12.60 | Kayla PortesIsland Trees | Island Trees '26 | Herricks Invitational | 2026 |
