| 1 | 10.95 | Lane 3Bellport | Bellport | Suffolk 2A County Championships | 2025 |
| 2 | 11.03 | Lane 4North Babylon | North Babylon | Suffolk 2A County Championships | 2025 |
| 3 | 11.12 | Lane 4West Babylon | West Babylon | Suffolk 2A County Championships | 2025 |
| 4 | 11.70 | Halle HazzardSt. Anthony's | St. Anthony's '17 | Post Easter Classic | 2016 |
| 5 | 11.74 | Alexa JacobsPort Jefferson | Port Jefferson '26 | North Babylon Invitational | 2025 |
| 6 | 11.84 | Janet MellorMount Sinai | Mount Sinai '10 | Girls' Suffolk Coaches Meet | 2009 |
| 7 | 11.90 | Precious MooreBay Shore | Bay Shore '04 | Suffolk County Girls | 2004 |
| 8 | 11.94 | Alexia DouglasBrentwood | Brentwood '15 | New York State Track & Field Championships | 2014 |
| 9 | 11.99 | Janel FrancisCopiague | Copiague '12 | Girls Division Championship Meet | 2011 |
| 10 | 12.00 | Kishana LongDeer Park | Deer Park '06 | Girls SQ Results 2B | 2006 |
| 11 | 12.00 | Alana WalkerHalf Hollow Hills East | Half Hollow Hills East '05 | Suffolk County Girls | 2004 |
| 12 | 12.04 | Chinque ThompsonStony Brook | Stony Brook | Stony Brook University - Wolfie Invitational | 2016 |
| 13 | 12.07 | Lisa LuchsingerSachem East | Sachem East '10 | Girls Division Championship Meet | 2010 |
| 14 | 12.10 | Angela SmithRiverhead | Riverhead '07 | Girls SQ Results 2B | 2006 |
| 15 | 12.10 | Chanel ChisholmNorth Babylon | North Babylon '07 | Suffolk County Girls | 2004 |
| 16 | 12.11 | Corine MageeWilliam Floyd | William Floyd '09 | Girls' Suffolk Coaches Meet | 2009 |
| 17 | 12.11 | Jada ObieHauppauge | Hauppauge '18 | Section XI State Qualifier Championships | 2018 |
| 18 | 12.13 | Melissa JuneSt. Anthony's | St. Anthony's '14 | Saint Anthony's Invitational | 2014 |
| 19 | 12.14 | Olivia HallsteinLongwood | Longwood '11 | Girls Division Championship Meet | 2010 |
| 20 | 12.15 | Brianna DavisBrentwood | Brentwood '20 | Section XI Girls Division Championships | 2018 |
| 21 | 12.15 | Elycia WilkersonConnetquot | Connetquot | Joe Brandi Relays - Day 1 | 2026 |
| 22 | 12.15 | Samara LawrenceNorth Babylon | North Babylon | Section XI County 2A Championships 2024 | 2024 |
| 23 | 12.16 | Melissa MichelsSachem North | Sachem North '14 | Smithtown Invitational | 2013 |
| 24 | 12.16 | Nevaeh PedrazaBellport | Bellport | Suffolk 2A County Championships | 2025 |
| 25 | 12.17 | Madison DuffyNorthport | Northport | North Babylon Invitational | 2025 |
| 26 | 12.19 | Alexandra WetterhahnHauppauge | Hauppauge '26 | Deer Park Invitational | 2026 |
| 27 | 12.20 | Sasa VannMercy | Mercy '12 | Bellport Invitational | 2012 |
| 28 | 12.2 | Carolyn RodehauSt. Anthony's | St. Anthony's '06 | Bob Beer Invitational | 2003 |
| 29 | 12.20 | Camryn DaleySt. Anthony's | St. Anthony's | North Shore Invitational | 2024 |
| 30 | 12.21 | Giavanna CiaravinoSt. Anthony's | St. Anthony's '22 | The Nassau Coaches Invitational | 2022 |
| 31 | 12.21 | Alyssa LetoSachem North | Sachem North '15 | New York State Track & Field Championships | 2014 |
| 32 | 12.22 | Imani McGheeBay Shore | Bay Shore '14 | Girls Division Championship Meet | 2014 |
| 33 | 12.23 | Victoria LundinSt. John the Baptist | St. John the Baptist '11 | League Championships | 2010 |
| 34 | 12.25 | Lane 1Center Moriches | Center Moriches | Section XI County 4B Championships 2024 | 2024 |
| 35 | 12.26 | Imani RichardsonSouthampton | Southampton '08 | Girls Division Championship Meet | 2008 |
| 36 | 12.26 | Zoe JacksonLongwood | Longwood | Suffolk A County Championships | 2026 |
| 37 | 12.27 | Laila ColeCenter Moriches | Center Moriches | Suffolk 4B County Championships | 2025 |
| 38 | 12.28 | Brittany KorsahWest Babylon | West Babylon '17 | Bob Pratt Memorial Track & Field Invitational | 2016 |
| 39 | 12.28 | Samantha WalzSt. Joseph by the Sea | St. Joseph by the Sea | St. Anthony's Invitational | 2024 |
| 40 | 12.29 | Cherish LoveNorth Babylon | North Babylon '20 | Chris Urban & Brittany Walsh Invitational | 2018 |
| 41 | 12.29 | Nailah JonesNorth Babylon | North Babylon '15 | Girls Division Championship Meet | 2014 |
| 42 | 12.30 | Liz CrowleyBayport-Blue Point | Bayport-Blue Point '07 | Girls SQ Results 2B | 2006 |
| 43 | 12.30 | Arnise GarrisonBellport | Bellport '13 | Bellport Invitational | 2012 |
| 44 | 12.30 | Kate DelGandioMount Sinai | Mount Sinai '22 | Westhampton Track Invite Girls | 2022 |
| 45 | 12.30 | Michaela MinconeSt. Anthony's | St. Anthony's '15 | Post Easter Classic | 2015 |
| 46 | 12.30 | Alexia MayoBrentwood | Brentwood '18 | Section XI Girls Division Championships | 2018 |
| 47 | 12.30 | Sarah MilitanoMiller Place | Miller Place '15 | Stony Brook University - Wolfie Invitational | 2018 |
| 48 | 12.30 | Akajia AtkinsCopiague | Copiague '18 | Section XI State Qualifier Championships | 2018 |
| 49 | 12.31 | Natalie GadsdenNorth Babylon | North Babylon '10 | Girls Division Championship Meet | 2010 |
| 50 | 12.31 | Chynna-Monica ChungSt. Anthony's | St. Anthony's '12 | NSCHSAA League Championships | 2012 |
| 51 | 12.31 | Nikki FogartySachem North | Sachem North '15 | Stony Brook University - Wolfie Invitational | 2016 |
| 52 | 12.32 | Tatianna KistnerWilliam Floyd | William Floyd '21 | Section XI State Qualifier Championships | 2018 |
| 53 | 12.32 | Dana CerboneMiddle Country | Middle Country '18 | Section XI Girls Division Championships | 2018 |
| 54 | 12.32 | Antoinette MillerWilliam Floyd | William Floyd '18 | Section XI Girls Division Championships | 2018 |
| 55 | 12.33 | Sara RondeNorthport | Northport '12 | Girls Division Championship Meet | 2011 |
| 56 | 12.33 | Rachel BudkeHauppauge | Hauppauge | North Babylon Invitational | 2025 |
| 57 | 12.34 | Roselyn OroyemiHalf Hollow Hills East | Half Hollow Hills East '14 | Section XI Individual Championships | 2014 |
| 58 | 12.34 | Sabrina MozartBrentwood | Brentwood '15 | Saint Anthony's Invitational | 2015 |
| 59 | 12.34 | Arielle DesirLongwood | Longwood '18 | Section XI Girls Division Championships | 2018 |
| 60 | 12.37 | Bianca BenavidesLongwood | Longwood '10 | Girls' Suffolk Coaches Meet | 2009 |
| 61 | 12.37 | Ashley LucasBabylon | Babylon '14 | New York State Track & Field Championships | 2014 |
| 62 | 12.38 | Amelia DeJoieSt. Anthony's | St. Anthony's | Massapequa Last Chance Invitational | 2025 |
| 63 | 12.39 | Bianca FungNorth Babylon | North Babylon '07 | Saint Anthony's Invitational | 2005 |
| 64 | 12.39 | Kaitlin WhitehornJohn Glenn | John Glenn '12 | Girls Division Championship Meet | 2011 |
| 65 | 12.39 | Alexandra GreavesWalt Whitman | Walt Whitman '16 | Bob Pratt Memorial Track & Field Invitational | 2016 |
| 66 | 12.39 | Christine LocherSt. John the Baptist | St. John the Baptist '06 | Saint Anthony's Invitational | 2005 |
| 67 | 12.39 | Isabella BoswellSachem North | Sachem North | Suffolk A County Championships | 2026 |
| 68 | 12.40 | Jessica AntoniadesSt. Anthony's | St. Anthony's '07 | NSCHSAA Spring Track & Field League Championships | 2006 |
| 69 | 12.40 | Ashley BellRiverhead | Riverhead '08 | Section XI Individual Championships | 2008 |
| 70 | 12.40 | Kate DulmovitsSayville | Sayville '07 | Section XI Division Championships | 2006 |
| 71 | 12.40 | Ashley GeorgeMiddle Country | Middle Country '08 | Girls SQ Results 2B | 2006 |
| 72 | 12.40 | Stefanny LaureanoBrentwood | Brentwood '10 | Girls Division Championship Meet | 2010 |
| 73 | 12.40 | Jackie GintyEast Islip | East Islip '17 | Girls Division Championship Meet | 2014 |
| 74 | 12.40 | Natasha WilliamsBellport | Bellport '04 | Suffolk County Girls | 2004 |
| 75 | 12.40 | Erica YoungBellport | Bellport '04 | Suffolk County Girls | 2004 |
| 76 | 12.40 | Summer DennisMiddle Country | Middle Country '04 | Suffolk County Girls | 2004 |
| 77 | 12.42 | Claire MathewsBrentwood | Brentwood | Suffolk A County Championships | 2026 |
| 78 | 12.43 | Ashely BellRiverhead | Riverhead '08 | Girls Division Championship Meet | 2008 |
| 79 | 12.43 | Emily TaussigSt. Anthony's | St. Anthony's '11 | League Championships | 2010 |
| 80 | 12.43 | Taylor FigueroaNorth Babylon | North Babylon '16 | Saint Anthony's Invitational | 2016 |
| 81 | 12.43 | Hillary EdwardsBrentwood | Brentwood '18 | Section XI State Qualifier Championships | 2018 |
| 82 | 12.44 | Christine WilkinsonCopiague | Copiague '08 | Section XI Individual Championships | 2008 |
| 83 | 12.45 | Chynna-Mo ChungSt. Anthony's | St. Anthony's '12 | League Championships | 2010 |
| 84 | 12.45 | Jaelyn DavisStony Brook | Stony Brook | Stony Brook Snowflake Classic | 2023 |
| 85 | 12.47 | Brittany JonesPatchogue-Medford | Patchogue-Medford '10 | Girls Division Championship Meet | 2009 |
| 86 | 12.47 | Mackenzie VickersBabylon | Babylon '11 | Girls Division Championship Meet | 2011 |
| 87 | 12.47 | Antoinette Butts MillerWalt Whitman | Walt Whitman '18 | Longwood Freshmen - Sophomore Championships | 2015 |
| 88 | 12.47 | Victoria ParisLongwood | Longwood | North Shore Invitational | 2025 |
| 89 | 12.47 | Adilia TrimWest Islip | West Islip | North Babylon Invitational | 2024 |
| 90 | 12.47 | Pria WilsonRoss School | Ross School '27 | Section XI State Qualifier | 2024 |
| 91 | 12.48 | Gianna BowmanSt. Anthony's | St. Anthony's | Paul Limmer Invitational | 2026 |
| 92 | 12.50 | Collette LaventureSt. Anthony's | St. Anthony's '07 | Saint Anthony's Invitational | 2005 |
| 93 | 12.50 | Hyacinth DeGuzmanBrentwood | Brentwood '08 | Suffolk County Girls | 2004 |
| 94 | 12.50 | Caprice ChurchAmityville | Amityville '04 | Suffolk County Girls | 2004 |
| 95 | 12.5 | Carol ScaliceComsewogue | Comsewogue '03 | Bob Beer Invitational | 2003 |
| 96 | 12.51 | Wilorda FrenelIslip | Islip '28 | Deer Park Invitational | 2026 |
| 97 | 12.52 | Keyshanna SymnsLongwood | Longwood '15 | Section XI Individual Championships | 2014 |
| 98 | 12.52 | Lucinda FreemanWyandanch | Wyandanch '07 | Girls Division Championship Meet | 2005 |
| 99 | 12.53 | Caitlin WhiteSt. Anthony's | St. Anthony's '07 | Saint Anthony's Invitational | 2005 |
| 100 | 12.54 | Nicole ScroKings Park | Kings Park '08 | Girls Division Championship Meet | 2008 |
