| 1 | 47.49 | Aidan PeterkinElmont Memorial | Elmont Memorial '26 | Section VIII State Qualifer Day 1 | 2025 |
| 2 | 47.6 | Elvis LewisWest Hempstead | West Hempstead '05 | State Qualifier | 2005 |
| 3 | 47.86 | Jonathan GreenwoodFreeport | Freeport '13 | Section VIII Class County Championships | 2013 |
| 4 | 48.2 | Alie BeuavaisHempstead | Hempstead '06 | Derrick Adkins Classic | 2006 |
| 5 | 48.21 | Terrance LivingstonGreat Neck South | Great Neck South '09 | Saint Anthony's Invitational | 2009 |
| 6 | 48.43 | McDonald DaleRoosevelt | Roosevelt '10 | Saint Anthony's Invitational | 2010 |
| 7 | 48.5 | Scott FaceyUniondale | Uniondale '04 | Derrick Adkins Holiday | 2004 |
| 8 | 48.5 | Alie BeauvisHempstead | Hempstead '06 | Derrick Adkins Holiday | 2005 |
| 9 | 48.54 | Luke GermanakosLynbrook | Lynbrook '15 | Hewlett Bulldog Invitational | 2015 |
| 10 | 48.6 | Atiba LiverpoolElmont | Elmont '05 | Class AAA County | 2005 |
| 11 | 48.7 | Dale McdonaldRoosevelt | Roosevelt '10 | 2009 Nassau Coaches Invitational - Boys | |
| 12 | 48.7 | Craig MeekinsChaminade | Chaminade '04 | Derrick Adkins Holiday | 2004 |
| 13 | 48.73 | Obadare AyoElmont | Elmont '13 | Section VIII Class County Championships | 2013 |
| 14 | 48.82 | Ayo ObadareElmont | Elmont '13 | Knight Time Invitational | 2012 |
| 15 | 48.87 | Donald McDonoughGarden City | Garden City | Port Washington Invitational | 2025 |
| 16 | 48.95 | Charles GilreathHoly Trinity | Holy Trinity '09 | Saint Anthony's Invitational | 2009 |
| 17 | 48.98 | Alex CollettiGarden City | Garden City '23 | Section VIII State Qualifier | 2023 |
| 18 | 48.99 | Tresean GoodwinUniondale | Uniondale '12 | Saint Anthony's Invitational | 2012 |
| 19 | 48.99 | Matthew JonesValley Stream Central | Valley Stream Central '14 | New York State Track & Field Championships | 2014 |
| 20 | 49.00 | David LewisFreeport | Freeport '10 | Saint Anthony's Invitational | 2010 |
| 21 | 49.03 | Saishun LamourUniondale | Uniondale '27 | Section 8 State Qualifer - Day 1 | 2026 |
| 22 | 49.1 | Chad AllenHempstead | Hempstead '08 | Derrick Adkins Classic | 2008 |
| 23 | 49.11 | Brandon RobinsonUniondale | Uniondale '22 | Section VIII County Championships Class AAA | 2022 |
| 24 | 49.20 | Alie BeauvaisHempstead | Hempstead '06 | Saint Anthony's Invitational | 2005 |
| 25 | 49.22 | Treyvon MaskBaldwin | Baldwin '13 | Section VIII Class County Championships | 2013 |
| 26 | 49.24 | Darrell TurnerBaldwin | Baldwin | Section VIII State Qualifer Day 1 | 2025 |
| 27 | 49.26 | Rlen RichardsElmont Memorial | Elmont Memorial | Section VIII State Qualifer Day 1 | 2025 |
| 28 | 49.28 | Tyrek BarneyHoly Trinity | Holy Trinity '09 | NSCHSAA League Championships | 2009 |
| 29 | 49.3 | Drew HarrisonWestbury | Westbury '04 | Derrick Adkins Holiday | 2004 |
| 30 | 49.31 | Dominic CollinsElmont Memorial | Elmont Memorial | Section VIII State Qualifer Day 1 | 2025 |
| 31 | 49.34 | Dylan VargasGeneral Douglas MacArthur | General Douglas MacArthur | Section VIII State Qualifier | 2023 |
| 32 | 49.36 | Fredrick ZennyKellenberg | Kellenberg '19 | Eastern States Invitational | 2018 |
| 33 | 49.39 | Dorian BoydFreeport | Freeport '25 | Section 8 AAA County Championship | 2025 |
| 34 | 49.4 | Brian BarrettFreeport | Freeport '05 | Division IA Championships | 2005 |
| 35 | 49.4 | Gabriel McLarenFreeport | Freeport '03 | Class A Counties | 2003 |
| 36 | 49.42 | Jeremy LissadeMepham | Mepham '17 | Section VIII Division 2A Championships | 2017 |
| 37 | 49.42 | Cole ThalheimerManhasset | Manhasset | Section 8 Class AA | 2024 |
| 38 | 49.43 | Dylan MurphyKellenberg | Kellenberg '13 | NSCHSAA League Championships | 2013 |
| 39 | 49.44 | Jaiden WilliamsElmont Memorial | Elmont Memorial '26 | Section 8 State Qualifer - Day 1 | 2026 |
| 40 | 49.46 | Caleb HarrisElmont Memorial | Elmont Memorial | Massapequa Last Chance Invitational | 2025 |
| 41 | 49.48 | Terrence ShawValley Stream Central | Valley Stream Central '07 | SA Inv results 2 | |
| 42 | 49.49 | Garcelin ElisiasValley Stream Central | Valley Stream Central '13 | Section VIII Class County Championships | 2013 |
| 43 | 49.49 | Connor WellbrockGarden City | Garden City | Section VIII State Qualifer Day 1 | 2025 |
| 44 | 49.55 | Rocco SignoreChaminade | Chaminade '13 | NSCHSAA League Championships | 2013 |
| 45 | 49.55 | Erik ChevezMacArthur | MacArthur '12 | Suffolk Officials Meet | 2012 |
| 46 | 49.56 | Ethan DavidsonUniondale | Uniondale '27 | Section 8 AAA County Championship | 2026 |
| 47 | 49.6 | Ben NaglerOceanside | Oceanside '04 | State Qualifier | 2004 |
| 48 | 49.61 | Christopher DeanOyster Bay | Oyster Bay | Section 8 State Qualifier | 2024 |
| 49 | 49.61 | Joseph MohauptDivision Avenue | Division Avenue | St. Anthony's Invitational | 2024 |
| 50 | 49.7 | Anthony LaneValley Stream Central | Valley Stream Central '04 | State Qualifier | 2004 |
| 51 | 49.71 | Jacob SchoenfeldValley Stream North | Valley Stream North '19 | Section VIII County Class 1 A - Boys | |
| 52 | 49.74 | Jonathan JacksonRoosevelt | Roosevelt '10 | Section One State Qualifier Championships | 2010 |
| 53 | 49.79 | Phil SellittoFarmingdale | Farmingdale | Stony Brook University - Wolfie Invitational | 2018 |
| 54 | 49.80 | Richard SemenickChaminade | Chaminade '07 | NSCHSAA Spring Track & Field League Championships | 2006 |
| 55 | 49.8 | Daine WatsonElmont | Elmont '07 | Derrick Adkins Holiday | 2007 |
| 56 | 49.85 | Momodou JobeRoosevelt | Roosevelt '10 | Section One State Qualifier Championships | 2011 |
| 57 | 49.86 | Sedgeley DupervalValley Stream North | Valley Stream North '24 | Section VIII County Championships Class AA | 2023 |
| 58 | 49.87 | Jason GutierrezValley Stream South | Valley Stream South '23 | Section VIII State Qualifier | 2023 |
| 59 | 49.89 | Jonathan SpenceSt. Dominic's | St. Dominic's '10 | NSCHSAA League Championships | 2009 |
| 60 | 49.9 | Anthony CelestinHempstead | Hempstead '08 | Derrick Adkins Classic | 2008 |
| 61 | 49.9 | Lamard HerronWestbury | Westbury '10 | 2009 Nassau Coaches Invitational - Boys | |
| 62 | 49.91 | Louis TorresMalverne | Malverne '26 | Section VIII State Qualifer Day 1 | 2025 |
| 63 | 49.91 | Jack BrosnanFarmingdale | Farmingdale '26 | Section 8 Class AAA | 2024 |
| 64 | 49.95 | Omar WaldenFreeport | Freeport '04 | Saint Anthony's Invitational | 2004 |
| 65 | 49.96 | Myles SmallHoly Trinity | Holy Trinity '22 | North Shore High School Invitational | 2022 |
| 66 | 49.97 | Elia AlbertsNorth Shore | North Shore '18 | Section VIII County Class 1 A - Boys | |
| 67 | 49.99 | Isayah ContrerasWellington C. Mepham | Wellington C. Mepham | Section 8 Division 2A Meet | 2024 |
| 68 | 50.0 | Darell HandlerNorth Shore | North Shore '07 | Conference IIVA | 2007 |
| 69 | 50.0 | Ashanti Foster-FelderFreeport | Freeport '10 | Division 1A Championships | |
| 70 | 50.00 | Dwayne PerryHoly Trinity | Holy Trinity '10 | Post Easter Classic | 2010 |
| 71 | 50.06 | Jonathan PrevostHoly Trinity | Holy Trinity '10 | Saint Anthony's Invitational | 2010 |
| 72 | 50.06 | Deniz SoybasBethpage | Bethpage '15 | Section VIII State Qualifier Meet | 2015 |
| 73 | 50.06 | Malcolm LivingstonRoosevelt | Roosevelt '18 | Section VIII County Class 2A - Boys | |
| 74 | 50.07 | TJ MagnoValley Stream North | Valley Stream North '15 | Section VIII Class 1A County Championships | 2015 |
| 75 | 50.09 | Justin GrantFreeport | Freeport '13 | Section VIII Class County Championships | 2013 |
| 76 | 50.10 | Marc ButtermanOceanside | Oceanside '12 | Suffolk Coaches Meet | 2012 |
| 77 | 50.1 | Caslon CatoWestbury | Westbury '05 | Class AA County | 2005 |
| 78 | 50.1 | Bill Allen-GordonFarmingdale | Farmingdale '05 | Class AAA County | 2005 |
| 79 | 50.10 | Kaedon TryeElmont Memorial | Elmont Memorial '27 | Section 8 AA County Championship | 2026 |
| 80 | 50.103 | Stephan LintonRoosevelt | Roosevelt '10 | Saint Anthony's Invitational | 2010 |
| 81 | 50.11 | Joshua BuckleyAcademy Charter (Sec 8.) | Academy Charter (Sec 8.) '28 | South Shore Frosh Soph Section 8 | 2026 |
| 82 | 50.12 | Christopher BorzorUniondale | Uniondale '18 | Knight Time Invitational | 2018 |
| 83 | 50.13 | Joseph BonomiGarden City | Garden City '24 | Section 8 State Qualifier | 2024 |
| 84 | 50.14 | Sebastian BuckeridgeFreeport | Freeport '18 | Section VIII County Class 3A - Boyls | |
| 85 | 50.14 | Christopher ByrneGarden City | Garden City '27 | Section 8 AA County Championship | 2026 |
| 86 | 50.2 | James StultzGreat Neck South | Great Neck South '05 | Class AA County | 2005 |
| 87 | 50.2 | Donovan MorganRoosevelt | Roosevelt '03 | Class C Counties | 2003 |
| 88 | 50.2 | Craig Alek-FinkelmanClarke | Clarke '05 | Class A County | 2005 |
| 89 | 50.21 | Salvadore InettiGeneral Douglas MacArthur | General Douglas MacArthur '27 | Section 8 AAA County Championship | 2026 |
| 90 | 50.23 | Jonathan DavisElmont | Elmont '15 | Hewlett Bulldog Invitational | 2015 |
| 91 | 50.23 | Trevon DevoreUniondale | Uniondale '16 | Saint Anthony's Invitational | 2016 |
| 92 | 50.23 | Brailyn JimenezHempstead | Hempstead | Section VIII County Championships Class AAA | 2023 |
| 93 | 50.24 | Jared HowesMassapequa | Massapequa '22 | The 18th Annual Bulldog Invite at Hewlett High School | 2022 |
| 94 | 50.26 | Sedgeley DupervalVal Stream North | Val Stream North | Section 8 Class AA | 2024 |
| 95 | 50.27 | Rashad TuckerFreeport | Freeport '17 | Nassau Coaches Track & Field Invitational | 2016 |
| 96 | 50.27 | Thomas StasichinMassapequa | Massapequa | Section 8 Class AAA | 2024 |
| 97 | 50.3 | Stephon BeckfordBaldwin | Baldwin '07 | Division 1B Championships | 2006 |
| 98 | 50.3 | Antoine DrummondFreeport | Freeport '09 | Division 1A Championships | |
| 99 | 50.3 | Matt NolanSouth Side | South Side '02 | Class A County | 2002 |
| 100 | 50.30 | Steven ElcockBaldwin | Baldwin '22 | The 18th Annual Bulldog Invite at Hewlett High School | 2022 |