| 1 | 39.89 | Brittany KorsahWest Babylon | West Babylon '17 | Section XI Indoor State Qualifier Meet | 2017 |
| 2 | 40.02 | D'Jai BakerNorth Babylon | North Babylon '16 | Indoor Track & Field Championships | 2014 |
| 3 | 40.04 | Elycia WilkersonConnetquot | Connetquot | Section XI State Qualifer Meet Day 2 | 2026 |
| 4 | 40.25 | Gianna PaulWalt Whitman | Walt Whitman '22 | Section XI Indoor State Qualifier Meet | 2020 |
| 5 | 40.25 | Alexa JacobsPort Jefferson | Port Jefferson '26 | Section XI State Qualifer Meet Day 2 | 2026 |
| 6 | 40.33 | Halle HazzardSt. Anthony's | St. Anthony's '17 | NSCHSAA Indoor League Championships | 2016 |
| 7 | 40.37 | Bella GaleasSachem East | Sachem East | Section XI State Qualifer Meet Day 2 | 2026 |
| 8 | 40.52 | Michele DayeHalf Hollow Hills West | Half Hollow Hills West '20 | Section XI Indoor State Qualifier Meet | 2020 |
| 9 | 40.70 | Melissa JuneSt. Anthony's | St. Anthony's '14 | NSCHSAA Indoor League Championships | 2014 |
| 10 | 40.86 | Amanda SteadMiller Place | Miller Place '17 | Section XI Indoor State Qualifier Meet | 2017 |
| 11 | 40.93 | Mary ChimezieHalf Hollow Hills East | Half Hollow Hills East '16 | Section XI Indoor State Qualifier Meet | 2015 |
| 12 | 40.97 | Lauren LoreficeWesthampton Beach | Westhampton Beach '15 | Section XI Indoor State Qualifier Meet | 2015 |
| 13 | 41.01 | Nadja AshleyWest Babylon | West Babylon '19 | Long Island Elite Track Invitational | 2019 |
| 14 | 41.05 | Analisse BatistaHuntington | Huntington '22 | Section XI Large School Championships | 2019 |
| 15 | 41.07 | Melissa CunninghamSt. Anthony's | St. Anthony's '21 | NSCHSAA Indoor League Championships | 2019 |
| 16 | 41.14 | Olivia HallsteinLongwood | Longwood '11 | Long Island Elite Track Invitational | 2011 |
| 17 | 41.15 | Bryana PadulaConnetquot | Connetquot '17 | Section XI Indoor State Qualifier Meet | 2017 |
| 18 | 41.19 | Wilorda FrenelIslip | Islip '28 | Section XI State Qualifer Meet Day 2 | 2026 |
| 19 | 41.35 | Jasmine DavisHauppauge | Hauppauge '15 | Indoor Track & Field Championships | 2014 |
| 20 | 41.35 | Shiseido RobinsonBrentwood | Brentwood '16 | Long Island Elite Track Invitational | 2014 |
| 21 | 41.36 | Janet MellorMount Sinai | Mount Sinai '10 | Section XI Indoor Track & Field State Qualifi | 2009 |
| 22 | 41.41 | Alexis HarperIslip | Islip '17 | Section XI Large School Championships | 2017 |
| 23 | 41.42 | Arielle DesirLongwood | Longwood '18 | Section XI Indoor State Qualifier Meet | 2018 |
| 24 | 41.43 | Adilia TrimWest Islip | West Islip | GIRLS Large Schools Championships | 2025 |
| 25 | 41.44 | Kyra FranksMount Sinai | Mount Sinai '22 | Section XI Indoor State Qualifier Meet | 2020 |
| 26 | 41.47 | Megan FiedlerSt. Anthony's | St. Anthony's '13 | Long Island Elite Track Invitational | 2011 |
| 27 | 41.47 | Melissa CunninghaSt. Anthony's | St. Anthony's '21 | Long Island Elite Track Invitational | 2018 |
| 28 | 41.48 | Laila ColeCenter Moriches | Center Moriches | Section XI State Qualifier Meet (Day 1) | 2025 |
| 29 | 41.49 | Caroline MulladyKings Park | Kings Park '22 | Section XI Girls Crossover B | 2019 |
| 30 | 41.54 | Imani HoodIslip | Islip | Section 11 State Quals | 2024 |
| 31 | 41.57 | Colby LubmanCommack | Commack '10 | Girls Large School Championships | 2009 |
| 32 | 41.58 | Brianna DavisBrentwood | Brentwood '20 | Section XI Girls Indoor League Championships | 2020 |
| 33 | 41.60 | Jessica GelibertBay Shore | Bay Shore '12 | Section XI Girls Indoor League Championships | 2012 |
| 34 | 41.66 | Arielle RossBellport | Bellport | Section XI State Qualifer Meet Day 2 | 2026 |
| 35 | 41.67 | Amelia DeJoieSt. Anthony's | St. Anthony's | NSCHSAA League Meet | 2025 |
| 36 | 41.70 | Nyha ButlerSt. Anthony's | St. Anthony's '20 | NSCHSAA Indoor League Championships | 2020 |
| 37 | 41.70 | Nickeela AustinCopiague | Copiague '16 | Section XI Girls Indoor League Championships | 2015 |
| 38 | 41.72 | Maritza BlanchardMiddle Country | Middle Country '18 | Section XI Indoor State Qualifier Meet | 2018 |
| 39 | 41.77 | Stefanny LaureanoBrentwood | Brentwood '10 | Section XI Large School Championships | 2010 |
| 40 | 41.78 | Alexandra WetterhahnHauppauge | Hauppauge '26 | Section XI State Qualifer Meet Day 2 | 2026 |
| 41 | 41.84 | Emma McLoughlinConnetquot | Connetquot '19 | Section XI Large School Championships | 2017 |
| 42 | 41.89 | Nicole HamiltonJohn Glenn | John Glenn '13 | Long Island Elite Track Invitational | 2013 |
| 43 | 41.89 | Brianna BurkleyHarborfields | Harborfields '18 | NSCHSAA Indoor League Championships | 2018 |
| 44 | 41.94 | Alyssa BarthelmesLindenhurst | Lindenhurst '13 | Section XI Large School Championships | 2013 |
| 45 | 41.96 | Alyssa LetoSachem North | Sachem North '15 | Section XI Girls Indoor League Championships | 2015 |
| 46 | 42.00 | Corine MageeWilliam Floyd | William Floyd '09 | Section XI Indoor Track & Field State Qualifi | 2009 |
| 47 | 42.01 | Morgan HepburnElwood / John Glenn | Elwood / John Glenn | Section XI State Qualifer Meet Day 2 | 2026 |
| 48 | 42.04 | Danielle SimonettiEast Islip | East Islip '26 | GIRLS League 3 Championship Meet | 2025 |
| 49 | 42.10 | Sarafina ScavoSachem East | Sachem East | GIRLS League Championships 1 | 2025 |
| 50 | 42.14 | Ariann RobinsonSachem East | Sachem East '22 | Section XI Indoor State Qualifier Meet | 2019 |
| 51 | 42.14 | Paige KeeferWest Babylon | West Babylon '17 | Section XI Girls Indoor League Championships | 2017 |
| 52 | 42.15 | Devin AbernethyRocky Point | Rocky Point '16 | Section XI Indoor State Qualifier Meet | 2015 |
| 53 | 42.16 | Sheisedo RobinsonBrentwood | Brentwood '16 | Section XI Indoor State Qualifier Meet | 2015 |
| 54 | 42.18 | Samantha QuigleyNorth Babylon | North Babylon '18 | Art Mitchell Class Meet | 2018 |
| 55 | 42.19 | Angelique PalmerBrentwood | Brentwood '18 | Section XI Girls Indoor League Championships | 2018 |
| 56 | 42.25 | Sarah DolphinSt. Anthony's | St. Anthony's '21 | NSCHSAA Indoor League Championships | 2020 |
| 57 | 42.30 | Cherish LoveNorth Babylon | North Babylon '20 | Jim Howard Meet | 2018 |
| 58 | 42.30 | Isabella MasottiMattituck | Mattituck '21 | Section XI Indoor State Qualifier Meet | 2020 |
| 59 | 42.33 | Nataly RamirezBrentwood | Brentwood '17 | Section XI Large School Championships | 2017 |
| 60 | 42.35 | Kerri GraberHalf Hollow Hills West | Half Hollow Hills West '13 | Section XI Large School Championships | 2013 |
| 61 | 42.35 | Chinelo NnakweSt. Anthony's | St. Anthony's '17 | NSCHSAA Indoor League Championships | 2017 |
| 62 | 42.38 | Adetola GoldMt. Sinai | Mt. Sinai '29 | Section XI GIRLS Crossover B (S1, S2) | 2025 |
| 63 | 42.40 | Alexandra GeositsDeer Park | Deer Park | Section 11 State Quals | 2024 |
| 64 | 42.41 | Leah HarrisCommack | Commack '29 | Section XI State Qualifer Meet Day 2 | 2026 |
| 65 | 42.42 | Jessica FaustinMiddle Country | Middle Country '20 | Section XI Girls Indoor League Championships | 2019 |
| 66 | 42.43 | Hope BilkeyHuntington | Huntington '23 | Section XI Indoor State Qualifier Meet | 2020 |
| 67 | 42.44 | Olicia WilliamsSt. Anthony's | St. Anthony's '12 | NSCHSAA Christmas Classic | 2008 |
| 68 | 42.47 | Gabby GriffinComsewogue | Comsewogue '18 | Section XI Indoor State Qualifier Meet | 2018 |
| 69 | 42.47 | Leah WilliamsBay Shore | Bay Shore | Section XI State Qualifier Meet (Day 1) | 2025 |
| 70 | 42.48 | Nialah JonesNorth Babylon | North Babylon '15 | Section XI Girls Indoor League Championships | 2013 |
| 71 | 42.51 | Jade FosterWilliam Floyd | William Floyd '19 | Section XI Girls Indoor League Championships | 2018 |
| 72 | 42.54 | Zhanna GreenSt. John the Baptist | St. John the Baptist '19 | NSCHSAA Christmas Classic | 2018 |
| 73 | 42.54 | Julia SmithWesthampton Beach | Westhampton Beach '20 | Section XI Girls Indoor League Championships | 2019 |
| 74 | 42.54 | Inocencia RodriguezBellport | Bellport | GIRLS Large Schools Championships | 2025 |
| 75 | 42.55 | Lisa LuchsingerSachem East | Sachem East '10 | Girls League Championships | 2010 |
| 76 | 42.55 | Shavanna RichardsNorth Babylon | North Babylon | Section XI State Qualifier Meet (Day 1) | 2025 |
| 77 | 42.56 | Carissa DavisCentral Islip | Central Islip '09 | Section 11 Cross Over D | 2009 |
| 78 | 42.57 | Victoria ParisLongwood | Longwood | GIRLS Large Schools Championships | 2025 |
| 79 | 42.58 | Lauren WangensteinConnetquot | Connetquot '15 | Section XI Indoor State Qualifier Meet | 2015 |
| 80 | 42.62 | Jessica BoosWest Babylon | West Babylon '19 | Section XI Girls Small School Championships | 2019 |
| 81 | 42.63 | Anisa ToppinBay Shore | Bay Shore '14 | Long Island Elite Track Invitational | 2011 |
| 82 | 42.64 | Christine DelianneWest Islip | West Islip '18 | Section XI Large School Championships | 2017 |
| 83 | 42.65 | Melissa MichelsSachem North | Sachem North '14 | Section XI Girls Indoor League Championships | 2013 |
| 84 | 42.66 | Valerie FinkeWesthampton Beach | Westhampton Beach '22 | Long Island Elite Track Invitational | 2019 |
| 85 | 42.69 | Martina KeithHalf Hollow Hills West | Half Hollow Hills West '19 | Section XI Girls Indoor League Championships | 2019 |
| 86 | 42.71 | Kate DulmovitsSayville | Sayville '07 | Girls Indoor Large and Small Championships 2007 | 2007 |
| 87 | 42.71 | Mia MiltonEastport-South Manor | Eastport-South Manor '19 | Section XI Girls Small School Championships | 2019 |
| 88 | 42.71 | Tylar JohnsonHalf Hollow Hills West | Half Hollow Hills West '25 | Section 11 State Quals | 2024 |
| 89 | 42.73 | Jackie GintyEast Islip | East Islip '17 | Jim Howard Meet | 2016 |
| 90 | 42.75 | Sarah MilitanoMiller Place | Miller Place '15 | Section XI Girls Indoor League Championships | 2015 |
| 91 | 42.77 | Alexandrea HarrioCentral Islip | Central Islip '18 | Section XI Indoor State Qualifier Meet | 2018 |
| 92 | 42.80 | Shannel SibbliesNorth Babylon | North Babylon '22 | Section XI Large School Championships | 2019 |
| 93 | 42.82 | Valerie MoiseCentral Islip | Central Islip '15 | Section XI Girls Indoor League Championships | 2015 |
| 94 | 42.83 | Paulina GasparisMiller Place | Miller Place '21 | Section XI Girls Small School Championships | 2019 |
| 95 | 42.83 | Tattan ThawCentral Islip | Central Islip '21 | Art Mitchell Large School Class Meet | 2020 |
| 96 | 42.84 | Janie TurekMount Sinai | Mount Sinai '11 | Girls Crossover Meet D | 2010 |
| 97 | 42.85 | Raymona CarrylSachem North | Sachem North '12 | Art Mitchell Memorial Meet | 2008 |
| 98 | 42.86 | Dana BegginsWest Babylon | West Babylon '17 | Section XI Girls Indoor League Championships | 2017 |
| 99 | 42.86 | Alexandrea HarriottCentral Islip | Central Islip '18 | Girls Crossover Meet B | 2015 |
| 100 | 42.88 | Emilie BlotiauAmityville | Amityville '09 | Girls Crossover Meet B | 2008 |
