| 1 | 6:22.96 | Lauren HarrisSachem East | Sachem East '17 | 46th Saint Anthony's Invitational | 2017 |
| 2 | 6:26.79 | Heather BulettiWesthampton Beach | Westhampton Beach '06 | Girls SQ Results 2B | 2006 |
| 3 | 6:36.00 | Gianna MauriSachem East | Sachem East '25 | Section XI State Qualifier | 2024 |
| 4 | 6:40.85 | Maria MichtaSachem | Sachem '04 | Section XI Individual Championships | 2004 |
| 5 | 6:41.49 | Margaret AtwoodSachem East | Sachem East '18 | Section XI State Qualifier Championships | 2018 |
| 6 | 6:45.52 | Katie MichtaSachem North | Sachem North '14 | Section XI Individual Championships | 2014 |
| 7 | 6:47.39 | Jessica GroverHalf Hollow Hills East | Half Hollow Hills East '19 | Section XI State Qualifier Championships | 2018 |
| 8 | 6:48.61 | Katharine NewhoffEast Islip | East Islip '15 | Saint Anthony's Invitational | 2015 |
| 9 | 6:48.69 | Allie BennettKings Park | Kings Park '15 | Section XI Individual Championships | 2014 |
| 10 | 6:49.49 | Keily RivasHuntington | Huntington '19 | Section XI Girls Division Championships | 2018 |
| 11 | 6:50.01 | Julianna WottawaSachem East | Sachem East '25 | Section XI State Qualifer | 2025 |
| 12 | 6:52.24 | Monika FarmerConnetquot | Connetquot '15 | Section XI Individual Championships | 2014 |
| 13 | 6:53.64 | Suzy FarberNorthport | Northport '12 | Girls Division Championship Meet | 2011 |
| 14 | 6:55.02 | Abbigail CallinanSachem East | Sachem East | Section XI State Qualifier | 2024 |
| 15 | 6:55.39 | Amy PetrocelliHauppauge | Hauppauge '17 | Saint Anthony's Invitational | 2016 |
| 16 | 6:55.44 | Sam FamilioCommack | Commack | Section XI State Qualifer | 2025 |
| 17 | 6:56.04 | Stephanie SaccenteKings Park | Kings Park '13 | Girls Division Championship Meet | 2012 |
| 18 | 6:56.27 | Jenna MonahanSachem East | Sachem East '07 | SA Inv results 2 | |
| 19 | 6:57.65 | Dylan CashinEast Hampton | East Hampton '24 | Section XI State Qualifier | 2024 |
| 20 | 6:58.31 | Brittany CollinsConnetquot | Connetquot '12 | Saint Anthony's Invitational | 2012 |
| 21 | 6:58.61 | Leah BulletiWesthampton Beach | Westhampton Beach '09 | Saint Anthony’s Invitational | |
| 22 | 6:58.72 | Erin BresnahanSachem North | Sachem North '09 | Girls Division Championship Meet | 2009 |
| 23 | 6:58.76 | Kelly MaranchuckSachem East | Sachem East '12 | Girls Division Championship Meet | 2012 |
| 24 | 6:59.19 | Kelsey JordanWesthampton Beach | Westhampton Beach '17 | 46th Saint Anthony's Invitational | 2017 |
| 25 | 7:00.19 | Amy CheungConnetquot | Connetquot '10 | Section XI Individual Championships | 2010 |
| 26 | 7:01.40 | Destiny LalaneBay Shore | Bay Shore '10 | Girls Division Championship Meet | 2009 |
| 27 | 7:02.93 | Sabrina MasonWesthampton Beach | Westhampton Beach '14 | Girls Division Championship Meet | 2014 |
| 28 | 7:03.59 | Katherine DituroHauppauge | Hauppauge '26 | East End Classic | 2026 |
| 29 | 7:04.34 | Samantha MaioriIslip | Islip '06 | Section XI Division Championships | 2006 |
| 30 | 7:04.75 | Diane SlackEast Islip | East Islip '06 | Girls SQ Results 2B | 2006 |
| 31 | 7:06.37 | Ashley O'SheaWard Melville | Ward Melville '09 | Girls Division Championship Meet | 2009 |
| 32 | 7:06.64 | Jennifer HalloranBay Shore | Bay Shore '11 | Section XI Individual Championships | 2010 |
| 33 | 7:06.94 | Diana BattagliaSachem East | Sachem East '09 | Girls Division Championship Meet | 2009 |
| 34 | 7:07.20 | Alyssa FurlaniSachem East | Sachem East '12 | Girls Division Championship Meet | 2012 |
| 35 | 7:07.74 | Brittany O'BrianBay Shore | Bay Shore '07 | Section XI Girls Team Championships | 2004 |
| 36 | 7:07.81 | Elisabeth BarnettBay Shore | Bay Shore '16 | Bob Pratt Memorial Track & Field Invitational | 2016 |
| 37 | 7:08.36 | Meghan BevanWest Islip | West Islip '16 | Saint Anthony's Invitational | 2016 |
| 38 | 7:09.62 | Katie VenierKings Park | Kings Park '15 | Section XI Individual Championships | 2014 |
| 39 | 7:09.66 | Erika VaradyHuntington | Huntington '19 | 46th Saint Anthony's Invitational | 2017 |
| 40 | 7:09.98 | Abigail CallinanSachem East | Sachem East '24 | St. Anthony's Invitational | 2024 |
| 41 | 7:10.40 | Erin O'FlahertyConnetquot | Connetquot '04 | Suffolk County Girls | 2004 |
| 42 | 7:11.16 | Amanda CatherallSachem East | Sachem East '12 | Girls Division Championship Meet | 2012 |
| 43 | 7:11.27 | Hazelle ArchagaSachem North | Sachem North '27 | Suffolk A County Championships | 2026 |
| 44 | 7:11.41 | Megan HoffmannSachem East | Sachem East '23 | North Shore High School Invitational | 2022 |
| 45 | 7:11.64 | Amy RichardsKings Park | Kings Park '06 | Section XI Division Championships | 2006 |
| 46 | 7:12.43 | Danielle ChiarelloSachem East | Sachem East '24 | Section XI State Qualifier | 2024 |
| 47 | 7:12.53 | Payton CotterNorthport | Northport | Section XI State Qualifier | 2024 |
| 48 | 7:12.55 | Ava CataniaConnetquot | Connetquot | Section XI State Qualifier | 2024 |
| 49 | 7:13.50 | Jourdann GreenLongwood | Longwood '12 | Bellport Invitational | 2012 |
| 50 | 7:13.65 | Samantha DelanoSachem East | Sachem East '17 | Saint Anthony's Invitational | 2016 |
| 51 | 7:14.44 | Emily ZahalbanBellport | Bellport '21 | Section XI State Qualifier Championships | 2018 |
| 52 | 7:14.82 | Nina PiacentineEast Hampton | East Hampton '16 | Saint Anthony's Invitational | 2016 |
| 53 | 7:15.60 | Jessica MichaelsSachem East | Sachem East '09 | Girls Division Championship Meet | 2009 |
| 54 | 7:15.80 | Lauren QuinnConnetquot | Connetquot | Section XI State Qualifer | 2025 |
| 55 | 7:17.34 | Jessica LevineSachem North | Sachem North '17 | 46th Saint Anthony's Invitational | 2017 |
| 56 | 7:17.60 | Nicole ArenthHuntington | Huntington '18 | 47th Saint Anthony's Invitational | 2018 |
| 57 | 7:17.61 | Katie VenireKings Park | Kings Park '15 | Smithtown Invitational | 2013 |
| 58 | 7:17.66 | Danielle CarsonHauppauge | Hauppauge '15 | Smithtown Invitational | 2013 |
| 59 | 7:17.90 | Courtney BofingerBayport-Blue Point | Bayport-Blue Point '14 | Section XI Individual Championships | 2014 |
| 60 | 7:18.01 | Sophia AlvarezSmithtown East | Smithtown East '26 | Section XI State Qualifer Day 2 | 2026 |
| 61 | 7:18.11 | Brittany RendeSayville | Sayville '08 | Section XI Individual Championships | 2008 |
| 62 | 7:18.30 | Keisha PearsonBellport | Bellport '05 | Suffolk County Girls | 2004 |
| 63 | 7:18.74 | Jamie FlemingSachem East | Sachem East '15 | Section XI Individual Championships | 2014 |
| 64 | 7:19.63 | Marina PettinicchiBellport | Bellport '11 | Girls Division Championship Meet | 2011 |
| 65 | 7:19.73 | Serena RoopnarineConnetquot | Connetquot '19 | Don Bohlinger Invitational | 2019 |
| 66 | 7:20.96 | Ruby RayPort Jefferson | Port Jefferson | East Hampton Invitational | 2023 |
| 67 | 7:21.02 | Daniella BarchiComsewogue | Comsewogue '20 | Don Bohlinger Invitational | 2019 |
| 68 | 7:21.09 | Kristen MagliolaShoreham-Wading River | Shoreham-Wading River '09 | Section XI Individual Championships | 2009 |
| 69 | 7:22.42 | Kylie TrettnerShoreham-Wading River | Shoreham-Wading River '13 | Girls Division Championship Meet | 2011 |
| 70 | 7:25.09 | Rowan AshbyHauppauge | Hauppauge '26 | Section XI State Qualifer Day 2 | 2026 |
| 71 | 7:25.29 | Julianna MolinoCommack | Commack '27 | Suffolk A County Championships | 2026 |
| 72 | 7:25.35 | Sara FarnanBay Shore | Bay Shore '16 | Suffolk Coaches Girls Track & Field Invitatio | 2014 |
| 73 | 7:25.90 | Brittany O'BrianBay Shore | Bay Shore | Saint Anthony's Invitational | 2004 |
| 74 | 7:26.41 | Amanda ZapatSachem East | Sachem East '13 | Saint Anthony's Invitational | 2010 |
| 75 | 7:26.67 | Jennifer CampbellSachem East | Sachem East '15 | Saint Anthony's Invitational | 2015 |
| 76 | 7:26.71 | Farrah WenglerWest Babylon | West Babylon '23 | The Don Bohlinger Invitational | 2023 |
| 77 | 7:27.50 | Elizabeth GiorgioNorthport | Northport '07 | Saint Anthony's Invitational | 2005 |
| 78 | 7:29.14 | Siara GuevaraMiller Place | Miller Place '18 | Girls Division Championship Meet | 2014 |
| 79 | 7:29.25 | Bianca PessoaSouthampton | Southampton '12 | Section XI Individual Championships | 2010 |
| 80 | 7:31.07 | Sarah LaPortaSachem East | Sachem East '13 | Girls Division Championship Meet | 2012 |
| 81 | 7:31.29 | Erika VaradayHuntington | Huntington '19 | Dennis Walker Championships | 2016 |
| 82 | 7:31.98 | Lena VergnesEast Hampton | East Hampton '13 | Girls Division Championship Meet | 2012 |
| 83 | 7:32.30 | Danielle ReffsinSmithtown West | Smithtown West '13 | Saint Anthony's Invitational | 2012 |
| 84 | 7:32.45 | Kianna PlummerConnetquot | Connetquot '19 | Section XI State Qualifier Championships | 2018 |
| 85 | 7:32.48 | Donna MacalusoHauppauge | Hauppauge '11 | Section XI Individual Championships | 2010 |
| 86 | 7:32.82 | Charley ArmstrongBayport-Blue Point | Bayport-Blue Point | St. Anthony's Invitational | 2024 |
| 87 | 7:33.01 | Alyssa EnglichConnetquot | Connetquot '12 | Saint Anthony's Invitational | 2012 |
| 88 | 7:33.17 | Nicolette PirragliWard Melville | Ward Melville '12 | Girls Division Championship Meet | 2011 |
| 89 | 7:33.19 | Julia DonahueIslip | Islip '14 | Girls Division Championship Meet | 2012 |
| 90 | 7:33.24 | Kayla HazelKings Park | Kings Park '11 | Girls Division Championship Meet | 2010 |
| 91 | 7:34.85 | Hayley DiCarloSachem East | Sachem East '18 | 47th Saint Anthony's Invitational | 2018 |
| 92 | 7:34.89 | Nicolette PirragliaWard Melville | Ward Melville '12 | Saint Anthony's Invitational | 2011 |
| 93 | 7:34.94 | Malak SaylaniCommack | Commack '27 | Section XI State Qualifer Day 2 | 2026 |
| 94 | 7:35.34 | D'Ashley LandrySachem North | Sachem North '11 | Saint Anthony's Invitational | 2011 |
| 95 | 7:35.44 | Katie WilliamsSachem North | Sachem North '07 | SA Inv results 2 | |
| 96 | 7:35.47 | Megan ValentinBay Shore | Bay Shore '11 | Saint Anthony's Invitational | 2011 |
| 97 | 7:35.70 | Amanda HarnosSachem East | Sachem East '20 | Longwood Freshmen - Sophomore Championships | 2018 |
| 98 | 7:36.34 | Lauren SwansonBay Shore | Bay Shore '17 | Bob Pratt Memorial Track & Field Invitational | 2016 |
| 99 | 7:36.38 | Alison HigginsKings Park | Kings Park '08 | Girls Division Championship Meet | 2008 |
| 100 | 7:36.71 | Emily CastillettiBayport-Blue Point | Bayport-Blue Point '14 | Saint Anthony's Invitational | 2014 |
