| 1 | 52.47 | Michelle CharlesSaint Mary's | Saint Mary's | North Shore Invitational | 2023 |
| 2 | 54.39 | Nylah PhillipsGeorge H. Hewlett | George H. Hewlett '26 | Section 8 AA County Championship | 2026 |
| 3 | 54.52 | Nicea JonesMalverne | Malverne | Section VIII State Qualifer Day 1 | 2025 |
| 4 | 54.9 | Charlene LipseyHempstead | Hempstead '09 | Derrick Adkins Classic | 2008 |
| 5 | 55.02 | Sean YangSyosset | Syosset '26 | Division 1A Championship | 2025 |
| 6 | 55.3 | Nikesha BrownHempstead | Hempstead '04 | Derrick Adkins Holiday | 2004 |
| 7 | 55.34 | Jeavon BenjaminHempstead | Hempstead '05 | Saint Anthony's Invitational | 2004 |
| 8 | 55.36 | Donna-Lee HyltonHempstead | Hempstead '09 | Saint Anthony's Invitational | 2009 |
| 9 | 55.55 | Candace TaylorFriends Acad | Friends Acad '14 | New York State Track & Field Championships | 2014 |
| 10 | 55.64 | Ariana MadeiraCold Spring Harbor | Cold Spring Harbor '29 | Section 8 AA County Championship | 2026 |
| 11 | 55.65 | Anissa MooreHempstead | Hempstead '23 | Section VIII State Qualifier | 2023 |
| 12 | 55.80 | Breanne BarnettBaldwin | Baldwin '26 | Division 2A Championship | 2025 |
| 13 | 55.83 | TianYu MaoSyosset | Syosset '26 | North Shore Invitational | 2025 |
| 14 | 55.87 | Ashlea McLaughlinUniondale | Uniondale '07 | New York State Track & Field Championships | 2006 |
| 15 | 55.90 | Gloria GuerrierWest Hempstead | West Hempstead '23 | Section VIII County Championships Class A | 2023 |
| 16 | 56.02 | Ashlea MacLoughlinUniondale | Uniondale | Saint Anthony’s Invitational | |
| 17 | 56.11 | Emma GallagherGarden City | Garden City '15 | Saint Anthony's Invitational | 2012 |
| 18 | 56.13 | Tori DanielsValley Stream South | Valley Stream South '23 | Section VIII County Championships Class A | 2022 |
| 19 | 56.30 | Victoria GuerrierWest Hempstead | West Hempstead '23 | Section VIII County Championships Class A | 2023 |
| 20 | 56.3 | Javan BenjimanHempstead | Hempstead '05 | Derrick Adkins Holiday | 2004 |
| 21 | 56.43 | Tori DanielsSouth Valley Stream | South Valley Stream | Section VIII State Qualifier | 2022 |
| 22 | 56.55 | Kyra LekanidesGarden City | Garden City '26 | Section 8 AA County Championship | 2026 |
| 23 | 56.59 | Kiyah OwensManhasset | Manhasset '16 | Saint Anthony's Invitational | 2016 |
| 24 | 56.77 | Grace GoldenSacred Heart | Sacred Heart '07 | New York State Track & Field Championships | 2006 |
| 25 | 56.8 | Keith KielszakWantagh | Wantagh | Greenand Gold Results | |
| 26 | 56.82 | Natalie LongobuccoGeneral Douglas MacArthur | General Douglas MacArthur | North Shore Invitational | 2024 |
| 27 | 56.9 | Sayako DaleyHempstead | Hempstead '06 | Division IA Championships | 2005 |
| 28 | 57.0 | Christie VerdierBaldwin | Baldwin '08 | Frosh/Soph Chanpionships | 2006 |
| 29 | 57.01 | Jahzara EmeliBaldwin | Baldwin | Section 8 AAA County Championship | 2025 |
| 30 | 57.09 | Taylor HennigGarden City | Garden City '12 | Saint Anthony's Invitational | 2010 |
| 31 | 57.1 | Aaron ZuckerWantagh | Wantagh '08 | Greenand Gold Results | |
| 32 | 57.15 | Stephney PryceElmont Memorial | Elmont Memorial | Section VIII State Qualifier | 2023 |
| 33 | 57.16 | Jasmine BlockerManhasset | Manhasset '10 | Saint Anthony's Invitational | 2010 |
| 34 | 57.17 | Niasia HardingHempstead | Hempstead '16 | Saint Anthony's Invitational | 2016 |
| 35 | 57.19 | Danielle MartinFreeport | Freeport '11 | Saint Anthony's Invitational | 2010 |
| 36 | 57.21 | Kimberly MacKayKellenberg | Kellenberg '11 | Saint Anthony's Invitational | 2010 |
| 37 | 57.27 | Emma VillaltaMassapequa | Massapequa '26 | Division 1A Championship | 2025 |
| 38 | 57.4 | Cara RostantValley Stream South | Valley Stream South '09 | Conference IIVA | 2007 |
| 39 | 57.48 | Laura JaegerGarden City | Garden City '14 | Saint Anthony's Invitational | 2012 |
| 40 | 57.49 | Andre-Anna RodneyElmont Memorial | Elmont Memorial | Section VIII County Championships Class AA | 2022 |
| 41 | 57.5 | Jefferson NavarreteSewanhaka | Sewanhaka | Greenand Gold Results | |
| 42 | 57.58 | Keandra AikensWestbury | Westbury '07 | Saint Anthony’s Invitational | |
| 43 | 57.67 | Alexandra WilliamsElmont Memorial | Elmont Memorial '22 | Section VIII County Championships Class AA | 2022 |
| 44 | 57.67 | Kristina CherringtonUniondale | Uniondale '16 | Section VIII State Qualifier Meet | 2014 |
| 45 | 57.68 | London WhiteUniondale | Uniondale | Division 1A Championship | 2025 |
| 46 | 57.7 | Kristen StuartDivision Avenue | Division Avenue '11 | 2009 Nassau Coaches Invitational - Girls | |
| 47 | 57.87 | DeAsia GreerFreeport | Freeport '16 | Nassau Coaches Track & Field Invitational | 2016 |
| 48 | 57.92 | Brooke LinHerricks | Herricks '26 | Section 8 AAA County Championship | 2026 |
| 49 | 58.00 | Tatyana GadsonHempstead | Hempstead '14 | Section VIII State Qualifier Meet | 2014 |
| 50 | 58.0 | Kevin DunnWantagh | Wantagh '06 | Greenand Gold Results | |
| 51 | 58.01 | Ellen ByrnesSacred Heart | Sacred Heart '18 | 47th Saint Anthony's Invitational | 2018 |
| 52 | 58.03 | Kristina CherringtUniondale | Uniondale '16 | New York State Track & Field Championships | 2014 |
| 53 | 58.06 | Caroline ReinerNorth Shore | North Shore '19 | Section VIII Division 4A Championships | 2018 |
| 54 | 58.10 | Deon PhillipsElmont | Elmont '11 | Saint Anthony's Invitational | 2010 |
| 55 | 58.22 | Odrine BelotKellenberg | Kellenberg '12 | NSCHSAA League Championships | 2012 |
| 56 | 58.23 | DeAnna MartinValley Stream South | Valley Stream South '19 | Section VIII County Class 1 A - Girls | |
| 57 | 58.28 | Nakacee McNabFreeport | Freeport '19 | Section VIII State Qualifier Meet | 2018 |
| 58 | 58.3 | Marie BlackwoodUniondale | Uniondale '03 | State Qualifier | 2002 |
| 59 | 58.31 | Megan JasinskiCold Spring Harbor | Cold Spring Harbor '25 | North Shore Invitational | 2023 |
| 60 | 58.32 | Zaria FullerUniondale | Uniondale '19 | Section VIII County Class 3A - Girls | |
| 61 | 58.33 | Mary Kate KennySacred Heart | Sacred Heart '15 | NSCHSAA League Championships | 2014 |
| 62 | 58.34 | Noveka McKayHempstead | Hempstead '12 | Saint Anthony's Invitational | 2011 |
| 63 | 58.36 | Kayleigh JamiesonGeorge H. Hewlett | George H. Hewlett '25 | Section 8 Division 3B Meet | 2024 |
| 64 | 58.37 | Brianna HarrisElmont | Elmont '18 | Saint Anthony's Invitational | 2016 |
| 65 | 58.38 | Jazmine FrayKellenberg | Kellenberg '15 | Saint Anthony's Invitational | 2014 |
| 66 | 58.4 | Nicole BankerEast Meadow | East Meadow '08 | Conference IB | 2007 |
| 67 | 58.4 | Shawna FoulkesLevittown Dist. | Levittown Dist. '06 | State Qualifier | 2004 |
| 68 | 58.49 | Makayla NoelElmont Memorial | Elmont Memorial | Section 8 AA County Championship | 2025 |
| 69 | 58.5 | Maegan KrifchinJFK Bellmore | JFK Bellmore '06 | Division 2A Championships | 2006 |
| 70 | 58.5 | Samekia McNabHempstead | Hempstead '03 | Class A Counties | 2003 |
| 71 | 58.51 | Jenny AguiarPort Washington | Port Washington '15 | Knight Time Invitational | 2015 |
| 72 | 58.57 | Gabriella BuisserethKellenberg | Kellenberg '18 | NSCHSAA League Championships | 2018 |
| 73 | 58.60 | Courtney SmithMassapequa | Massapequa '05 | Nassau Coaches Meet | 2005 |
| 74 | 58.6 | Dana LevittLynbrook | Lynbrook '08 | Division 3A Championships | |
| 75 | 58.63 | Bianca ST. CilienUniondale | Uniondale '18 | Section VIII State Qualifier Meet | 2018 |
| 76 | 58.68 | Brianna CivilElmont Memorial | Elmont Memorial '28 | Section 8 AA County Championship | 2026 |
| 77 | 58.7 | Marlene RickettsWestbury | Westbury '10 | 2009 Nassau Coaches Invitational - Girls | |
| 78 | 58.7 | Sanique LevyHempstead | Hempstead '05 | Division IA Championships | 2005 |
| 79 | 58.8 | Ayanna KellyMalverne | Malverne '08 | Greenand Gold Results2006 | |
| 80 | 58.81 | Mia MartinezValley Stream North | Valley Stream North '21 | CACC Track & Field Championship Meet (Day 2) | 2025 |
| 81 | 58.83 | Giuliana PortaroGlen Cove | Glen Cove '29 | Section VIII "North Shore" Frosh/Soph Meet | 2024 |
| 82 | 58.9 | Vanessa ThompsonUniondale | Uniondale '07 | Division 1A Championships | 2006 |
| 83 | 58.9 | Stacy-Ann BrownHempstead | Hempstead '03 | Class A Counties | 2003 |
| 84 | 58.9 | Margot LevyBaldwin | Baldwin '02 | Class A County | 2002 |
| 85 | 58.9 | Ruben RosalesValley Stream North | Valley Stream North | Greenand Gold Results | |
| 86 | 58.92 | Lana AlvarezFriends Academy (Li) | Friends Academy (Li) '28 | Section 8 AA County Championship | 2025 |
| 87 | 58.93 | Nicolette SandsFrank Carey | Frank Carey '11 | Saint Anthony's Invitational | 2011 |
| 88 | 58.95 | Beatriz ChavarriaPort Washington | Port Washington '17 | Section VIII Class 3A County Championships | 2015 |
| 89 | 58.97 | Sydney SopchakMacArthur | MacArthur '15 | Massapequa Under the Lights | 2015 |
| 90 | 58.99 | Nyree BacchusGreat Neck South | Great Neck South '22 | Section VIII County Championships Class AAA | 2022 |
| 91 | 59.00 | Diona WoodsFreeport | Freeport '12 | Saint Anthony's Invitational | 2011 |
| 92 | 59.01 | Jasmine BelcherKellenberg | Kellenberg '12 | NSCHSAA League Championships | 2011 |
| 93 | 59.07 | Jessica AlessiSyosset | Syosset | Section 8 Division 1A Meet | 2024 |
| 94 | 59.15 | Alexa BenunPaul D. Schrieber / Port Washi | Paul D. Schrieber / Port Washi | Section VIII County Championships Class AAA | 2022 |
| 95 | 59.19 | Latanya EslerinHempstead | Hempstead | SA Inv results 2 | |
| 96 | 59.19 | Lauren BowerClarke | Clarke '15 | Section VIII State Qualifier Meet | 2015 |
| 97 | 59.21 | Meghan WendlekenKellenberg | Kellenberg '08 | NSCHSAA League Championships | 2008 |
| 98 | 59.21 | Megan BazziniPort Washington | Port Washington '18 | Section VIII County Class 3A - Girls | |
| 99 | 59.22 | Karlie DeanSacred Heart | Sacred Heart | Farmingdale State College Invitational | 2010 |
| 100 | 59.24 | Kaitlyn BrandowMassapequa | Massapequa '17 | Section VIII Class 3A County Championships | 2015 |
