| 1 | 53.4 | Gabriel McLarenFreeport | Freeport '03 | State Qualifier | 2003 |
| 2 | 53.67 | Jon HallMepham | Mepham '06 | Boys State Meet Results | 2006 |
| 3 | 54.2 | Michael WrightUniondale | Uniondale '05 | State Qualifier | 2005 |
| 4 | 54.4 | Kurt KinkeadValley Stream Central | Valley Stream Central '03 | State Qualifier | 2003 |
| 5 | 54.6 | Brian BarrettFreeport | Freeport '05 | State Qualifier | 2005 |
| 6 | 54.69 | Lorvens HyppoliteFarmingdale | Farmingdale '18 | Section VIII State Qualifier Meet | 2018 |
| 7 | 54.7 | Stephon BeckfordBaldwin | Baldwin '07 | Conference IB | 2007 |
| 8 | 54.7 | Brandon CamilleBaldwin | Baldwin '08 | Derrick Adkins Classic | 2008 |
| 9 | 54.81 | Daniel EliaSacred Heart | Sacred Heart | Stony Brook University - Wolfie Invitational | 2016 |
| 10 | 55.00 | Idowu BamisileFarmingdale | Farmingdale | Stony Brook University - Wolfie Invitational | 2016 |
| 11 | 55.02 | Windell WallaceLawrence | Lawrence '07 | SA Inv results 2 | |
| 12 | 55.1 | Seren OzcanSyosset | Syosset '03 | Class A County | 2002 |
| 13 | 55.29 | Russell JohnsonBaldwin | Baldwin '18 | Section VIII State Qualifier Meet | 2018 |
| 14 | 55.30 | Kenneth CiullaFrank Carey | Frank Carey '18 | Section VIII State Qualifier Meet | 2018 |
| 15 | 55.43 | Tristan BrownBaldwin | Baldwin | Section VIII County Championships Class AAA | 2023 |
| 16 | 55.7 | Caslon CatoWestbury | Westbury '05 | Class AA County | 2005 |
| 17 | 55.7 | Stanley RalphWestbury | Westbury '03 | State Qualifier | 2003 |
| 18 | 55.8 | Jon De BeaumontFarmingdale | Farmingdale '04 | State Qualifier | 2004 |
| 19 | 55.82 | Dylan VargasGeneral Douglas MacArthur | General Douglas MacArthur | Section VIII County Championships Class AAA | 2023 |
| 20 | 55.90 | Thomas ValeriusValley Stream Central | Valley Stream Central '07 | SA Inv results 2 | |
| 21 | 55.9 | Adam TaddeoOceanside | Oceanside '04 | State Qualifier | 2004 |
| 22 | 56.05 | Luke PascaleRoslyn | Roslyn '13 | Section VIII Class County Championships | 2013 |
| 23 | 56.08 | Tyler EdmeadeUniondale | Uniondale '18 | Section VIII County Class 3A - Boyls | |
| 24 | 56.08 | Patrick CollIsland Trees | Island Trees | Section 8 A County Championships | 2025 |
| 25 | 56.10 | Malik BarrettUniondale | Uniondale '19 | Section VIII County Class 3A - Boyls | |
| 26 | 56.1 | Sean DepuyLevittown Dist. | Levittown Dist. '03 | Class A Counties | 2003 |
| 27 | 56.16 | Marcus LeeSouth Great Neck | South Great Neck | Section VIII State Qualifer Day 1 | 2025 |
| 28 | 56.17 | Kyle CartwrightOyster Bay | Oyster Bay '13 | Section VIII Class County Championships | 2013 |
| 29 | 56.18 | Nyder ChardonetteUniondale | Uniondale '12 | Saint Anthony's Invitational | 2011 |
| 30 | 56.28 | Damilola BabalolaWest Hempstead | West Hempstead '22 | Section VIII County Championships Class A | 2022 |
| 31 | 56.30 | Nathaniel MercerUniondale | Uniondale '09 | Saint Anthony's Invitational | 2009 |
| 32 | 56.3 | Mark-Anthony GilbertBaldwin | Baldwin '05 | State Qualifier | 2004 |
| 33 | 56.31 | Thomas BonsignoreDivision Avenue | Division Avenue | Section 8 State Qualifier | 2024 |
| 34 | 56.31 | Dominick RiosVal Stream North | Val Stream North '27 | Port Washington Invitational | 2025 |
| 35 | 56.38 | Evan AugusteGreat Neck South | Great Neck South '10 | Saint Anthony's Invitational | 2010 |
| 36 | 56.38 | Matthew WilshereManhasset | Manhasset '13 | Section VIII Class County Championships | 2013 |
| 37 | 56.39 | Tremaine DevoreUniondale | Uniondale '13 | Saint Anthony's Invitational | 2012 |
| 38 | 56.40 | Krystofer RinggoldUniondale | Uniondale '15 | Section VIII State Qualifier Meet | 2015 |
| 39 | 56.47 | Trevon CampbellFreeport | Freeport '19 | Section VIII Division 1A Championships | 2018 |
| 40 | 56.5 | Christopher BierChaminade | Chaminade '03 | Derrick Adkins Classic | 2003 |
| 41 | 56.55 | Getho BrevetteWestbury | Westbury '15 | Section VIII State Qualifier Meet | 2015 |
| 42 | 56.55 | Nelson CrawfordMalverne | Malverne | Section VIII State Qualifier | 2023 |
| 43 | 56.7 | Sean TullySyosset | Syosset '05 | Class AAA County | 2005 |
| 44 | 56.7 | Brian ChabackOceanside | Oceanside '03 | Division IA | 2003 |
| 45 | 56.7 | Tim HickeyWest Hempstead | West Hempstead '08 | Division 3A Championships | |
| 46 | 56.73 | Treyvon MaskBaldwin | Baldwin '13 | Section VIII Class County Championships | 2013 |
| 47 | 56.77 | Kai RodgerJFK Bellmore | JFK Bellmore '22 | Section VIII County Championships Class AA | 2022 |
| 48 | 56.8 | Dan ValenteGarden City | Garden City '02 | State Qualifier | 2002 |
| 49 | 56.84 | Dan VaronMassapequa | Massapequa '11 | Saint Anthony's Invitational | 2011 |
| 50 | 56.86 | Brian CaldereroJFK Bellmore | JFK Bellmore '14 | Section VIII State Qualifier Meet | 2014 |
| 51 | 56.90 | Romain Saint GermainWestbury | Westbury '12 | Saint Anthony's Invitational | 2012 |
| 52 | 56.92 | Jahiem FooteUniondale | Uniondale | Section 8 Division 1A Meet | 2024 |
| 53 | 56.97 | Marco EcheandiaFloral Park Memorial | Floral Park Memorial '15 | Section VIII State Qualifier Meet | 2014 |
| 54 | 56.99 | Nathaniel SmallHoly Trinity | Holy Trinity '14 | NSCHSAA League Championships | 2014 |
| 55 | 57.00 | Brian SchmidtKellenberg | Kellenberg '07 | NSCHSAA Spring Track & Field League Championships | 2006 |
| 56 | 57.04 | Christopher CorderoMassapequa | Massapequa '25 | Section 8 AAA County Championship | 2025 |
| 57 | 57.08 | Daniel DeLunaMassapequa | Massapequa '13 | Section VIII Class County Championships | 2013 |
| 58 | 57.1 | Wayne StewartWestbury | Westbury '10 | Division 3A Championships | |
| 59 | 57.1 | Danny HuGreat Neck South | Great Neck South '06 | Division IIB Championships | 2005 |
| 60 | 57.12 | Djovanny JosephHoly Trinity | Holy Trinity '10 | Saint Anthony's Invitational | 2010 |
| 61 | 57.12 | Choi JerryHerricks | Herricks '11 | Saint Anthony's Invitational | 2011 |
| 62 | 57.12 | Gabe DasilvaHerricks | Herricks '13 | Section VIII Class County Championships | 2013 |
| 63 | 57.17 | Nicholas JoestenChaminade | Chaminade '14 | NSCHSAA League Championships | 2014 |
| 64 | 57.17 | Jacob SchoenfeldValley Stream North | Valley Stream North '19 | Massapequa Under the Lights | 2018 |
| 65 | 57.2 | Kieran LangWheatley | Wheatley '10 | 2009 Nassau Coaches Invitational - Boys | |
| 66 | 57.25 | Nahjeem LoweRoosevelt | Roosevelt '14 | Section VIII Class County Championships | 2014 |
| 67 | 57.3 | Adam CafarellaSouth Side | South Side '05 | Class AA County | 2005 |
| 68 | 57.35 | Andrew YardeHoly Trinity | Holy Trinity '14 | NSCHSAA League Championships | 2014 |
| 69 | 57.39 | Jayden FrancisHewlett | Hewlett '19 | Section VIII County Class 2A - Boys | |
| 70 | 57.4 | Chris BauerNorth Shore | North Shore '05 | Division IVA | 2005 |
| 71 | 57.40 | Kelechi AkaziUniondale | Uniondale '27 | Section 8 State Qualifer - Day 1 | 2026 |
| 72 | 57.41 | Jayden Zarco-De La CruzLong Beach | Long Beach | Section 8 Class AAA | 2024 |
| 73 | 57.42 | Mark RobertsUniondale | Uniondale | Section VIII State Qualifer Day 1 | 2025 |
| 74 | 57.43 | Dylan BestlerMineola | Mineola '14 | Section VIII Class County Championships | 2014 |
| 75 | 57.44 | Isaiah PaigeValley Stream North | Valley Stream North '15 | Section VIII Class 1A County Championships | 2015 |
| 76 | 57.5 | Matthew VincelliLynbrook | Lynbrook '09 | Division 3A Championships | |
| 77 | 57.50 | Jordon QuinnFreeport | Freeport '24 | Section VIII County Championships Class AAA | 2023 |
| 78 | 57.61 | Daniel GalantoSacred Heart | Sacred Heart | Farmingdale State College Invitational | 2010 |
| 79 | 57.63 | Jonathan PrevostHoly Trinity | Holy Trinity '10 | NSCHSAA League Championships | 2009 |
| 80 | 57.63 | Cole MillerManhasset | Manhasset '27 | Section 8 State Qualifer - Day 1 | 2026 |
| 81 | 57.66 | Jonathon XavierValley Stream North | Valley Stream North '22 | Section VIII Championships Division 3A | 2022 |
| 82 | 57.66 | Joshua StevensonRoosevelt | Roosevelt '15 | Section VIII Class 1A County Championships | 2015 |
| 83 | 57.66 | Tyler ParrisUniondale | Uniondale '16 | Section VIII Class County Championships | 2014 |
| 84 | 57.69 | Michael SheahanBethpage | Bethpage '25 | Section 8 AA County Championship | 2025 |
| 85 | 57.7 | Dan LernerHewlett | Hewlett '02 | State Qualifier | 2002 |
| 86 | 57.72 | Kevin AmmiratiKellenberg | Kellenberg '09 | NSCHSAA League Championships | 2008 |
| 87 | 57.80 | Connor BarrettKellenberg | Kellenberg '12 | NSCHSAA League Championships | 2012 |
| 88 | 57.80 | Noah SerretteLawrence | Lawrence '16 | Section VIII Class 1A County Championships | 2015 |
| 89 | 57.88 | Nicholas VazquezWheatley | Wheatley '16 | Section VIII State Qualifier Meet | 2015 |
| 90 | 57.88 | John Della RattaNorth Shore | North Shore '24 | Section 8 Class A | 2024 |
| 91 | 57.90 | Jonathon XavierNorth Valley Stream | North Valley Stream | Section VIII State Qualifier | 2022 |
| 92 | 57.9 | Thomas BethellMassapequa | Massapequa '06 | Division 1A Championships | 2006 |
| 93 | 57.92 | Kiran GabburWheatley School | Wheatley School '26 | Division 4B Championship | 2026 |
| 94 | 58.0 | Mike DigregorioSyosset | Syosset '06 | Division 1A Championships | 2006 |
| 95 | 58.01 | John TurnbullEast Meadow | East Meadow | Section 8 Class AAA | 2024 |
| 96 | 58.05 | David AlexandreFarmingdale | Farmingdale '27 | Section 8 AAA County Championship | 2026 |
| 97 | 58.06 | Cerone SamuelUniondale | Uniondale '28 | Division 1A Championship | 2026 |
| 98 | 58.07 | Wilmino SainbertEast Meadow | East Meadow '28 | Division 2A Championship | 2026 |
| 99 | 58.1 | Brendan CreightonGarden City | Garden City '09 | 2009 Derrick Adkins Classic - Boys | |
| 100 | 58.10 | Seren OaranSyosset | Syosset | Derrick Adkins Classic | 2002 |
