| 1 | 5:01.81 | Molly DearieWard Melville | Ward Melville '15 | NSCHSAA League Championships | 2010 |
| 2 | 5:18.30 | Taylor MitchellSt. Anthony's | St. Anthony's '15 | NSCHSAA League Championships | 2010 |
| 3 | 5:19.89 | Abigail CaulfieldNorthport | Northport '17 | NSCHSAA League Championships | 2012 |
| 4 | 5:25.94 | Emily FiorilloSt. John the Baptist | St. John the Baptist '17 | NSCHSAA League Championships | 2012 |
| 5 | 5:29.75 | Annie FiorilloSt. John the Baptist | St. John the Baptist '15 | NSCHSAA League Championships | 2010 |
| 6 | 5:30.52 | Alexis PastorelliHuntington | Huntington '17 | NSCHSAA League Championships | 2012 |
| 7 | 5:30.85 | Allison SchleierSt. John the Baptist | St. John the Baptist '16 | NSCHSAA League Championships | 2010 |
| 8 | 5:30.92 | Emily CarlsonSt. Anthony's | St. Anthony's '18 | NSCHSAA League Championships | 2012 |
| 9 | 5:31.11 | Alexis SiegelSt. John the Baptist | St. John the Baptist '16 | NSCHSAA League Championships | 2010 |
| 10 | 5:31.24 | Christiane WeberSt. Anthony's | St. Anthony's '17 | NSCHSAA League Championships | 2012 |
| 11 | 5:31.34 | Allison MillerLongwood | Longwood '16 | NSCHSAA League Championships | 2010 |
| 12 | 5:32.63 | Hannah RussSt. Anthony's | St. Anthony's '17 | NSCHSAA League Championships | 2012 |
| 13 | 5:33.30 | Lauren BonomiSt. John the Baptist | St. John the Baptist '17 | NSCHSAA League Championships | 2012 |
| 14 | 5:33.85 | Louise KoepeleHuntington | Huntington '17 | NSCHSAA League Championships | 2012 |
| 15 | 5:35.58 | Grace TierneySt. Anthony's | St. Anthony's '15 | NSCHSAA League Championships | 2010 |
| 16 | 5:36.08 | Meredith HaberfieldSt. John the Baptist | St. John the Baptist '19 | NSCHSAA League Championships | 2012 |
| 17 | 5:38.84 | Morgan HaberfieldSt. John the Baptist | St. John the Baptist '15 | NSCHSAA League Championships | 2010 |
| 18 | 5:41.10 | Carolann TonnaSt. Anthony's | St. Anthony's '18 | NSCHSAA League Championships | 2012 |
| 19 | 5:41.78 | Jill SchleierSt. John the Baptist | St. John the Baptist '19 | NSCHSAA League Championships | 2012 |
| 20 | 5:42.33 | Sabrina McCarronSt. Anthony's | St. Anthony's '16 | NSCHSAA League Championships | 2010 |
| 21 | 5:42.76 | Paige FurmanSt. Anthony's | St. Anthony's '19 | NSCHSAA League Championships | 2012 |
| 22 | 5:43.20 | Catherine LalorSt. Anthony's | St. Anthony's '15 | NSCHSAA League Championships | 2010 |
| 23 | 5:48.95 | Madison RussSt. Anthony's | St. Anthony's '15 | NSCHSAA League Championships | 2010 |
| 24 | 5:56.64 | Kayla WieczorekSt. Anthony's | St. Anthony's '17 | NSCHSAA League Championships | 2012 |
| 25 | 5:57.69 | Aubrey BlanthornSt. Anthony's | St. Anthony's '17 | NSCHSAA League Championships | 2012 |
| 26 | 5:58.46 | Amanda MillerHalf Hollow Hills West | Half Hollow Hills West '20 | NSCHSAA League Championships | 2012 |
| 27 | 6:01.20 | Meghan SlatterySt. Anthony's | St. Anthony's '16 | NSCHSAA League Championships | 2010 |
| 28 | 6:01.89 | Caitlyn McDuffeeSt. Anthony's | St. Anthony's '16 | NSCHSAA League Championships | 2010 |
| 29 | 6:02.37 | Kelly FielderSt. John the Baptist | St. John the Baptist '16 | NSCHSAA League Championships | 2010 |
| 30 | 6:03.92 | Erin MorrisroeHuntington | Huntington '17 | NSCHSAA League Championships | 2012 |
| 31 | 6:07.43 | Joanna MeyerSt. Anthony's | St. Anthony's '16 | NSCHSAA League Championships | 2010 |
| 32 | 6:15.32 | Julia BrittanSt. John the Baptist | St. John the Baptist '17 | NSCHSAA League Championships | 2012 |
| 33 | 6:16.32 | Catherine TintiSt. John the Baptist | St. John the Baptist '19 | NSCHSAA League Championships | 2012 |
| 34 | 6:22.93 | Katherine HoulihanBay Shore | Bay Shore '17 | NSCHSAA League Championships | 2012 |
| 35 | 6:30.01 | Christine DelianneWest Islip | West Islip '18 | NSCHSAA League Championships | 2012 |
| 36 | 6:31.96 | Amelia WardSt. John the Baptist | St. John the Baptist '15 | NSCHSAA League Championships | 2010 |
| 37 | 6:34.17 | Ciara HealySt. John the Baptist | St. John the Baptist '19 | NSCHSAA League Championships | 2012 |
| 38 | 6:35.09 | Margaret TerryMercy | Mercy '17 | NSCHSAA League Championships | 2012 |
| 39 | 6:36.96 | Claire McGrathSt. John the Baptist | St. John the Baptist '19 | NSCHSAA League Championships | 2012 |
| 40 | 6:41.61 | Audrey NigroSouthampton | Southampton '18 | NSCHSAA League Championships | 2012 |
| 41 | 6:41.69 | Keira McIsaacSt. Anthony's | St. Anthony's '15 | NSCHSAA League Championships | 2010 |
| 42 | 6:51.18 | Annie MannerSt. John the Baptist | St. John the Baptist '16 | NSCHSAA League Championships | 2010 |
| 43 | 6:53.23 | Mary MaloneySt. John the Baptist | St. John the Baptist '17 | NSCHSAA League Championships | 2012 |
| 44 | 6:56.55 | Grace ReganSt. Anthony's | St. Anthony's '18 | NSCHSAA League Championships | 2012 |
| 45 | 6:58.31 | Isabel ChristieSt. Anthony's | St. Anthony's '19 | NSCHSAA League Championships | 2012 |
| 46 | 7:02.78 | Juliette VincentiSt. John the Baptist | St. John the Baptist '15 | NSCHSAA League Championships | 2010 |
| 47 | 7:07.53 | Isabella SampinoSt. Anthony's | St. Anthony's '19 | NSCHSAA League Championships | 2012 |
| 48 | 7:10.70 | Brittany StokesSt. John the Baptist | St. John the Baptist '17 | NSCHSAA League Championships | 2012 |
| 49 | 7:12.21 | Brianna MahonSt. Anthony's | St. Anthony's '16 | NSCHSAA League Championships | 2010 |
| 50 | 7:13.65 | Lucia BerrySt. John the Baptist | St. John the Baptist '19 | NSCHSAA League Championships | 2012 |
| 51 | 7:20.74 | Angelina SchottSt. John the Baptist | St. John the Baptist '19 | NSCHSAA League Championships | 2012 |
| 52 | 7:23.07 | Hannah McGowanSt. Anthony's | St. Anthony's '16 | NSCHSAA League Championships | 2010 |
| 53 | 7:26.24 | Anne WallaceSt. John the Baptist | St. John the Baptist '19 | NSCHSAA League Championships | 2012 |
| 54 | 7:32.00 | Bianca CaceresSt. Anthony's | St. Anthony's '15 | NSCHSAA League Championships | 2010 |
| 55 | 7:32.26 | Shannon KavanaghMercy | Mercy '16 | NSCHSAA League Championships | 2010 |
| 56 | 7:46.39 | Stephanie HahnSt. John the Baptist | St. John the Baptist '17 | NSCHSAA League Championships | 2012 |
| 57 | 8:07.75 | Makayla LairdSt. John the Baptist | St. John the Baptist '17 | NSCHSAA League Championships | 2012 |
| 58 | 8:15.45 | Alana GatesSt. John the Baptist | St. John the Baptist '19 | NSCHSAA League Championships | 2012 |
| 59 | 8:19.69 | Melissa BrezaultSt. Anthony's | St. Anthony's '17 | NSCHSAA League Championships | 2012 |
