| 1 | 47.39 | Patrick FarmerSt. Anthony's | St. Anthony's '10 | Saint Anthony's Invitational | 2010 |
| 2 | 47.40 | Keith HinnantBay Shore | Bay Shore '04 | Suffolk County Boys | 2004 |
| 3 | 48.01 | Josiah PriceWest Babylon | West Babylon | Section XI State Qualifer | 2025 |
| 4 | 48.09 | James CiaccioSt. Anthony's | St. Anthony's '25 | Port Washington Invitational | 2025 |
| 5 | 48.13 | Evan FraserPatchogue-Medford | Patchogue-Medford '26 | Suffolk A County Championships | 2026 |
| 6 | 48.34 | Payton HazzardSt. Anthony's | St. Anthony's '11 | Eastern States Invitational | 2011 |
| 7 | 48.35 | Kory FitzgeraldHalf Hollow Hills West | Half Hollow Hills West '15 | Section XI State Qualifier Championships | 2015 |
| 8 | 48.43 | Joseph NorrbyEast Islip | East Islip '25 | Section XI State Qualifer | 2025 |
| 9 | 48.48 | Luis SalazarHalf Hollow Hills West | Half Hollow Hills West | Commack Invitational | 2026 |
| 10 | 48.50 | Kyree JohnsonHuntington | Huntington '17 | Section XI State Qualifier Championships | 2015 |
| 11 | 48.50 | Kaiden WhiteIslip | Islip | Suffolk 3A County Championships | 2025 |
| 12 | 48.52 | Jaden LyonsSt. Anthony's | St. Anthony's '22 | North Shore High School Invitational | 2022 |
| 13 | 48.53 | Aleksandar ZdravkovicSmithtown West | Smithtown West '20 | Stony Brook Snowflake Classic | 2022 |
| 14 | 48.55 | Owen LaubSouthampton | Southampton '11 | Section XI Individual Championships | 2011 |
| 15 | 48.59 | Tyrone TillmanLongwood | Longwood | East End Classic | 2026 |
| 16 | 48.61 | Wayne WilliamsStony Brook | Stony Brook | Stony Brook University - Wolfie Invitational | 2017 |
| 17 | 48.66 | Jaquan HollandBellport | Bellport '10 | Section XI Individual Championships | 2009 |
| 18 | 48.74 | Y'Majesty AllenHuntington | Huntington '14 | Boys Division Championship Meet | 2014 |
| 19 | 48.75 | Mychael FabioWalt Whitman | Walt Whitman '08 | Boys Division Championship Meet | 2008 |
| 20 | 48.76 | Vincent JacksonAmityville | Amityville '13 | Section XI Individual Championships | 2013 |
| 21 | 48.80 | Ian MorganAmityville | Amityville '04 | Suffolk County Boys | 2004 |
| 22 | 48.81 | Nicolas LavazoliMiddle Country | Middle Country '21 | Stony Brook Snowflake Classic | 2022 |
| 23 | 48.83 | Taylor ChaneySt. Anthony's | St. Anthony's '09 | NSCHSAA League Championships | 2009 |
| 24 | 48.86 | Ibrahim AbubakaBrentwood | Brentwood '11 | Section XI Individual Championships | 2011 |
| 25 | 48.89 | Marlon MontagueSt. Anthony's | St. Anthony's '14 | NSCHSAA League Championships | 2013 |
| 26 | 48.93 | Infinite TuckerHuntington | Huntington '16 | Boys Division Championship Meet | 2015 |
| 27 | 48.94 | Marco D'AlessandroHalf Hollow Hills West | Half Hollow Hills West | Don Bohlinger Invitational | 2025 |
| 28 | 48.95 | Zavier JenkinsWilliam Floyd | William Floyd | Section XI State Qualifer Day 2 | 2026 |
| 29 | 48.97 | Terrell JeffreyHauppauge | Hauppauge '25 | Section XI State Qualifer | 2025 |
| 30 | 49.02 | Amari AlcindorAmityville Memorial | Amityville Memorial | Don Bohlinger Invitational | 2025 |
| 31 | 49.04 | George ErazoNorth Babylon | North Babylon '10 | Boys Division Championship Meet | 2010 |
| 32 | 49.04 | Raphael RotherBay Shore | Bay Shore '11 | Section XI Individual Championships | 2011 |
| 33 | 49.05 | Joglanio AlcindorWard Melville | Ward Melville | Commack Invitational | 2026 |
| 34 | 49.07 | Warner Cooley IIISt. Anthony's | St. Anthony's '11 | NSCHSAA League Championships | 2011 |
| 35 | 49.10 | Cory BentonSouthampton | Southampton '06 | Saint Anthony’s Invitational | |
| 36 | 49.12 | Hunter BurrellSt. John the Baptist | St. John the Baptist '11 | NSCHSAA League Championships | 2011 |
| 37 | 49.13 | Josaih PriceWest Babylon | West Babylon | Section XI County 2A Championships 2024 | 2024 |
| 38 | 49.20 | Demarr AultmanHalf Hollow Hills West | Half Hollow Hills West '10 | Boys Division Championship Meet | 2010 |
| 39 | 49.22 | Kyle WatkinsLongwood | Longwood '15 | Boys Division Championship Meet | 2014 |
| 40 | 49.25 | Sebastian PierreSt. Anthony's | St. Anthony's '14 | NSCHSAA League Championships | 2014 |
| 41 | 49.26 | James LaguerreWard Melville | Ward Melville '15 | Boys Division Championship Meet | 2015 |
| 42 | 49.28 | Desmond CalderonLongwood | Longwood | North Shore Invitational | 2024 |
| 43 | 49.30 | Harold JamisonHalf Hollow Hills West | Half Hollow Hills West '09 | Boys Division Championship Meet | 2009 |
| 44 | 49.31 | Chris TingueWard Melville | Ward Melville '04 | Section XI Individual Championships | 2004 |
| 45 | 49.33 | Michael HuebnerShoreham-Wading River | Shoreham-Wading River | Suffolk 4B County Championships | 2025 |
| 46 | 49.35 | Louis SantelliSt. Anthony's | St. Anthony's '14 | Stony Brook University - Wolfie Invitational | 2016 |
| 47 | 49.40 | Joshua GaliMiddle Country | Middle Country '13 | Section XI Individual Championships | 2013 |
| 48 | 49.41 | Dennis ScruggsBellport | Bellport '08 | SA Inv results 2 | |
| 49 | 49.43 | Luke CoulterRiverhead | Riverhead '16 | Chris Urban & Brittany Walsh Invitational | 2016 |
| 50 | 49.46 | Fernando ToledoComsewogue | Comsewogue '19 | Section XI Boys Division Championships | 2018 |
| 51 | 49.49 | Nicholas DuchatellierHalf Hollow Hills West | Half Hollow Hills West '18 | Section XI State Qualifier Championships | 2018 |
| 52 | 49.5 | Robert BarnesBrentwood | Brentwood '08 | Derrick Adkins Classic | 2008 |
| 53 | 49.50 | Hugh BernardAmityville | Amityville '09 | Boys Division Championship Meet | 2009 |
| 54 | 49.50 | Travis CorreaBellport | Bellport '12 | Suffolk Officials Meet | 2012 |
| 55 | 49.50 | Michael FitzgeraldSt. John the Baptist | St. John the Baptist '06 | NSCHSAA Spring Track & Field League Championships | 2006 |
| 56 | 49.50 | Liam KnightEast Hampton | East Hampton '26 | East End Classic | 2026 |
| 57 | 49.51 | Gregory BoveWest Islip | West Islip '18 | Section XI Boys Division Championships | 2018 |
| 58 | 49.53 | Dennis LocherSt. John the Baptist | St. John the Baptist '09 | NSCHSAA League Championships | 2009 |
| 59 | 49.53 | Zach FloodBayport-Blue Point | Bayport-Blue Point '11 | Section XI Individual Championships | 2010 |
| 60 | 49.56 | Austin SperlComsewogue | Comsewogue '15 | Section XI State Qualifier Championships | 2015 |
| 61 | 49.57 | Dylan DilevoMiddle Country | Middle Country '11 | Section XI Individual Championships | 2011 |
| 62 | 49.59 | John CinnanteJohn Glenn | John Glenn '09 | Section XI Individual Championships | 2009 |
| 63 | 49.61 | Ian HaneyMiddle Country | Middle Country '09 | Boys Division Championship Meet | 2008 |
| 64 | 49.61 | Mario MayenCenter Moriches | Center Moriches '12 | St. Joseph's College Track & Field Invitational | 2015 |
| 65 | 49.62 | Mohammad AbubakarBrentwood | Brentwood '13 | Section XI Individual Championships | 2013 |
| 66 | 49.62 | Jeremiah DavisConnetquot | Connetquot | Suffolk B County Championships | 2026 |
| 67 | 49.63 | Alex ToranNorthport | Northport '26 | Suffolk B County Championships | 2026 |
| 68 | 49.64 | Kyle PrestinWalt Whitman | Walt Whitman '11 | Saint Anthony's Invitational | 2011 |
| 69 | 49.64 | Isaiah ClaiborneNorthport | Northport '18 | Section XI State Qualifier Championships | 2018 |
| 70 | 49.66 | Danzell FranklinCopiague | Copiague '09 | Section XI Individual Championships | 2009 |
| 71 | 49.67 | Frederic Fils AimeHalf Hollow Hills West | Half Hollow Hills West '13 | Boys Division Championship Meet | 2013 |
| 72 | 49.67 | Malakye MossHalf Hollow Hills East (Hhh) | Half Hollow Hills East (Hhh) | Section XI State Qualifer | 2025 |
| 73 | 49.67 | Jayden MillerSt. John the Baptist | St. John the Baptist | NSCHSAA Championships | 2025 |
| 74 | 49.68 | Christopher GiuntaSt. Anthony's | St. Anthony's '07 | SA Inv results 2 | |
| 75 | 49.69 | Adekola AdegbiteSt. Anthony's | St. Anthony's '12 | Saint Anthony's Invitational | 2012 |
| 76 | 49.69 | Matthew CappockSmithtown West | Smithtown West '17 | Stony Brook Snowflake Classic | 2022 |
| 77 | 49.70 | Tysheem GriffinAmityville | Amityville '16 | Saint Anthony's Invitational | 2016 |
| 78 | 49.71 | Xavier CruzMiddle Country | Middle Country '26 | Section XI State Qualifer Day 1 | 2026 |
| 79 | 49.74 | Luke LaffertyEastport-South Manor | Eastport-South Manor '16 | Westhampton Beach Invitational | 2016 |
| 80 | 49.74 | Bryce JohnsonHalf Hollow Hills West | Half Hollow Hills West '14 | Boys Division Championship Meet | 2014 |
| 81 | 49.75 | Daniel PaganCommack | Commack | St. Anthony's Invitational | 2024 |
| 82 | 49.76 | Stanley CadetNorth Babylon | North Babylon '16 | Saint Anthony's Invitational | 2016 |
| 83 | 49.78 | Davon ChristopherSachem North | Sachem North '11 | Section XI Individual Championships | 2009 |
| 84 | 49.79 | Vincenzo BattagliaWard Melville | Ward Melville '12 | Boys Division Championship Meet | 2012 |
| 85 | 49.81 | Thabiti LeeNorth Babylon | North Babylon '25 | Section XI County 2A Championships 2024 | 2024 |
| 86 | 49.82 | Davin LiElwood / John Glenn | Elwood / John Glenn | St. Anthony's Invitational | 2024 |
| 87 | 49.83 | Denzel HardyHalf Hollow Hills West | Half Hollow Hills West '16 | Boys Division Championship Meet | 2015 |
| 88 | 49.85 | Thomas DuPlessisSt. John the Baptist | St. John the Baptist '12 | NSCHSAA League Championships | 2012 |
| 89 | 49.85 | Avery WalasCommack | Commack '14 | 68th Suffolk County Relays | 2014 |
| 90 | 49.86 | Aaron McFaddenCopiague | Copiague '15 | Chris Urban & Brittany Walsh Invitational | 2015 |
| 91 | 49.87 | Jerel WilliamsEast Islip | East Islip '12 | Boys Division Championship Meet | 2012 |
| 92 | 49.87 | Julian BoltonConnetquot | Connetquot | Suffolk 1A County Championships | 2025 |
| 93 | 49.89 | Nicholas AndersonHalf Hollow Hills East (Hhh) | Half Hollow Hills East (Hhh) | Suffolk B County Championships | 2026 |
| 94 | 49.90 | Benton CorySouthampton | Southampton '06 | Saint Anthony's Invitational | 2005 |
| 95 | 49.90 | Matthew PapajohnHampton Bays | Hampton Bays | Section XI State Qualifier | 2024 |
| 96 | 49.91 | Justin BovePort Jefferson | Port Jefferson '14 | New York State Track & Field Championships | 2014 |
| 97 | 49.96 | Jacob RobinsonRiverhead | Riverhead '15 | Section XI State Qualifier Championships | 2015 |
| 98 | 49.97 | Rashim GainesAmityville | Amityville '09 | Saint Anthony's Invitational | 2009 |
| 99 | 49.97 | Lawrence LeakeHuntington | Huntington '17 | Saint Anthony's Invitational | 2016 |
| 100 | 49.98 | Dan HolstSmithtown West | Smithtown West '07 | Section XI Division Championships | 2006 |
