| 1 | 10.5 | Joseph ScherH. Frank Carey | H. Frank Carey '08 | Division 2A Championships | 2006 |
| 2 | 10.5 | Chaisen PettusRoosevelt | Roosevelt '05 | State Qualifier | 2005 |
| 3 | 10.6 | Daine WatsonElmont | Elmont '07 | Division IIA | 2005 |
| 4 | 10.6 | Jermaine ArtwellUniondale | Uniondale '04 | State Qualifier | 2003 |
| 5 | 10.6 | Amechie EgbeValley Stream Central | Valley Stream Central '07 | State Qualifier | 2007 |
| 6 | 10.6 | Nicholas GuscottBaldwin | Baldwin '08 | State Qualifier | 2007 |
| 7 | 10.65 | Leroy BarrettRoosevelt | Roosevelt '26 | Paul Limmer Invitational | 2026 |
| 8 | 10.7 | Marc MauroLocust Valley | Locust Valley '10 | 2009 Nassau Coaches Invitational - Boys | |
| 9 | 10.70 | Derek ArmstrongHoly Trinity | Holy Trinity '14 | Boys Freshmen - Sophomore Championships | 2012 |
| 10 | 10.70 | Shaka ShomariHoly Trinity | Holy Trinity '15 | Post Easter Classic | 2015 |
| 11 | 10.7 | Darrel CrearyFreeport | Freeport '05 | State Qualifier | 2005 |
| 12 | 10.7 | Jon AmoonaHewlett | Hewlett '02 | Class A County | 2002 |
| 13 | 10.7 | Onix SalvaMalverne | Malverne '02 | Class B County | 2002 |
| 14 | 10.7 | James LowderRoslyn | Roslyn '02 | Division IIIB | 2002 |
| 15 | 10.7 | Chike AguFloral Park Memorial | Floral Park Memorial '08 | State Qualifier | 2008 |
| 16 | 10.72 | Kazeem ScottFreeport | Freeport | Section VIII State Qualifier | 2023 |
| 17 | 10.78 | Jovanni ParkinsonFarmingdale | Farmingdale | Track & Field Twilight Mini Meets - 1st Night | 2023 |
| 18 | 10.79 | Christopher BorzorUniondale | Uniondale '18 | 47th Saint Anthony's Invitational | 2018 |
| 19 | 10.79 | Christopher DeanOyster Bay | Oyster Bay | Section 8 Class A | 2024 |
| 20 | 10.79 | Brandon ThweattBaldwin | Baldwin '26 | Blue and White Invitational | 2025 |
| 21 | 10.8 | Terrence ShawValley Stream Central | Valley Stream Central '07 | Division IIA | 2005 |
| 22 | 10.8 | James McClenicRoosevelt | Roosevelt '09 | 2009 Nassau Coaches Invitational - Boys | |
| 23 | 10.8 | Steven MatthewH. Frank Carey | H. Frank Carey '10 | Division 2A Championships | |
| 24 | 10.8 | Charles RossFarmingdale | Farmingdale '05 | State Qualifier | 2005 |
| 25 | 10.8 | Michael WrightUniondale | Uniondale '05 | Division IA Championships | 2005 |
| 26 | 10.8 | Drew HarrisonWestbury | Westbury '04 | State Qualifier | 2004 |
| 27 | 10.8 | Xavier BrooksMalverne | Malverne '10 | 2009 Nassau Coaches Invitational - Boys | |
| 28 | 10.8 | Justin RollingUniondale | Uniondale '02 | Class A County | 2002 |
| 29 | 10.8 | Elvis LewisWest Hempstead | West Hempstead '05 | State Qualifier | 2003 |
| 30 | 10.8 | Clark HindsFloral Park Memorial | Floral Park Memorial '08 | Nassau County Coaches | 2008 |
| 31 | 10.85 | Kimani LewisElmont Memorial | Elmont Memorial '23 | Section VIII County Championships Class AA | 2023 |
| 32 | 10.86 | Damian SamuelUniondale | Uniondale '06 | Class AAA | 2006 |
| 33 | 10.86 | Apollo SimmonsWestbury | Westbury | Section 8 Division 1B Meet | 2024 |
| 34 | 10.88 | Zaahir ForbesValley Stream Central | Valley Stream Central '18 | Section VIII Division 2A Championships | 2018 |
| 35 | 10.88 | Nigel WrightBaldwin | Baldwin | Blue and White Invitational | 2025 |
| 36 | 10.89 | Darnelle MickensWestbury | Westbury '10 | Saint Anthony's Invitational | 2010 |
| 37 | 10.89 | Dylan DoneganHicksville | Hicksville | The Jim McGlynn Classic | 2024 |
| 38 | 10.9 | Samuel CuffeySouth Side | South Side '07 | State Qualifier | 2007 |
| 39 | 10.9 | Alix LamarreMepham | Mepham '09 | 2009 Nassau Coaches Invitational - Boys | |
| 40 | 10.90 | Daniel WilliamsRoslyn | Roslyn '20 | Section VIII Division 3A Championships | 2018 |
| 41 | 10.90 | Giordano WilliamsUniondale | Uniondale '19 | Section VIII Division 1A Championships | 2018 |
| 42 | 10.9 | James ClarkeWestbury | Westbury '03 | Class B County | 2002 |
| 43 | 10.9 | James StultzGreat Neck South | Great Neck South '05 | State Qualifier | 2005 |
| 44 | 10.9 | Gavin WebbBaldwin | Baldwin '05 | State Qualifier | 2004 |
| 45 | 10.9 | Richard BeckerLynbrook | Lynbrook '02 | Division IIIB | 2002 |
| 46 | 10.9 | Steven SunmonuJericho | Jericho '04 | Division IIIB | 2003 |
| 47 | 10.9 | Anthony BarnettUniondale | Uniondale '08 | Division 1A Championships | |
| 48 | 10.9 | Eddie NicolasWest Hempstead | West Hempstead '06 | Division 3B Championships | 2006 |
| 49 | 10.9 | Lesly AllonceValley Stream Central | Valley Stream Central '06 | Division 2A Championships | 2006 |
| 50 | 10.9 | Nestor AguiarWest Hempstead | West Hempstead '08 | Nassau Coaches Meet | 2007 |
| 51 | 10.9 | Naheem McNeilHempstead | Hempstead '07 | Class AAA County | 2007 |
| 52 | 10.90 | Dominic InzerillaWellington C. Mepham | Wellington C. Mepham | Section VIII State Qualifier | 2023 |
| 53 | 10.91 | Xavier AllenWestbury | Westbury '18 | Section VIII State Qualifier Meet | 2018 |
| 54 | 10.92 | Jeremy LissadeMepham | Mepham '17 | Nassau Coaches Track & Field Invitational | 2016 |
| 55 | 10.92 | Isaiah DavisElmont Memorial | Elmont Memorial '24 | Section VIII State Qualifier | 2023 |
| 56 | 10.92 | Okikijesu FashakinAcademy Charter (Sec 8.) | Academy Charter (Sec 8.) '26 | Paul Limmer Invitational | 2026 |
| 57 | 10.93 | Myles SmallHoly Trinity | Holy Trinity '22 | North Shore High School Invitational | 2022 |
| 58 | 10.93 | Josh LinsterLong Beach | Long Beach '15 | Section VIII Class 3A County Championships | 2015 |
| 59 | 10.94 | Thomas SmallFloral Park Memorial | Floral Park Memorial | Division 3B Championship | 2025 |
| 60 | 10.95 | Gregory MatzelleFrank Carey | Frank Carey '16 | Nassau Coaches Track & Field Invitational | 2016 |
| 61 | 10.95 | Joshua BeloffSacred Heart | Sacred Heart | Stony Brook University - Wolfie Invitational | 2016 |
| 62 | 10.95 | Josiah BrackenMineola | Mineola | Section 8 Division 3B Meet | 2024 |
| 63 | 10.95 | Ethan HindsVal Stream South | Val Stream South '26 | Section 8 A County Championship | 2026 |
| 64 | 10.97 | Nick GoscottBaldwin | Baldwin | Suffolk Coaches Meet | 2008 |
| 65 | 10.97 | Damion Gordon Jr.Kellenberg | Kellenberg | NSCHSAA & NSCHSGAA Easter Classic | 2025 |
| 66 | 10.97 | Erric HayesHoly Trinity | Holy Trinity | Paul Limmer Invitational | 2026 |
| 67 | 10.97 | Joshua BuckleyAcademy Charter (Sec 8.) | Academy Charter (Sec 8.) '28 | Section 8 AA County Championship | 2026 |
| 68 | 10.98 | Jaquan SmithElmont | Elmont '11 | Saint Anthony's Invitational | 2011 |
| 69 | 10.98 | Oraldini Llunga MpoySanford H. Calhoun | Sanford H. Calhoun '26 | Section 8 AA County Championship | 2026 |
| 70 | 11.0 | Chris ParkerMepham | Mepham '08 | Class AA County | 2007 |
| 71 | 11.0 | Travis WhiteLawrence | Lawrence '09 | 2009 Nassau Coaches Invitational - Boys | |
| 72 | 11.0 | Erin ParkerRoosevelt | Roosevelt '12 | 2009 Nassau Coaches Invitational - Boys | |
| 73 | 11.0 | Chinedu AguFloral Park Memorial | Floral Park Memorial '08 | Nassau County Coaches | 2008 |
| 74 | 11.0 | Shannon MasonManhasset | Manhasset '07 | Nassau Coaches Meet | 2007 |
| 75 | 11.00 | Jaden AntoineHoly Trinity | Holy Trinity '18 | Boys Freshmen - Sophomore Championships | 2016 |
| 76 | 11.0 | Dale McdonaldRoosevelt | Roosevelt '10 | Class A County | 2008 |
| 77 | 11.0 | Jeremy GrubardClarke | Clarke '02 | Division IIIB | 2002 |
| 78 | 11.0 | Zhivargo SimmonsGlen Cove | Glen Cove '02 | Class B County | 2002 |
| 79 | 11.0 | Taariq CayneH. Frank Carey | H. Frank Carey '06 | Class AA Counties | 2004 |
| 80 | 11.0 | Terance MorganRoosevelt | Roosevelt '05 | Class A County | 2005 |
| 81 | 11.0 | Stephen DesilusElmont | Elmont '06 | Division IIA | 2005 |
| 82 | 11.0 | Daniel BillianClarke | Clarke '08 | State Qualifier | 2008 |
| 83 | 11.0 | Bovell CarruthersUniondale | Uniondale '07 | Class AAA County | 2007 |
| 84 | 11.0 | Michael MatiasHerricks | Herricks '09 | Division 2A Championships | |
| 85 | 11.0 | Lance KingOceanside | Oceanside '09 | Division 1A Championships | |
| 86 | 11.0 | Dante LeslieLong Beach | Long Beach '09 | Division 1B Championships | 2008 |
| 87 | 11.0 | Kyle FitzpatickLong Beach | Long Beach '10 | State Qualifier | 2008 |
| 88 | 11.0 | Joseph EdwardsBaldwin | Baldwin '09 | 2009 Nassau Coaches Invitational - Boys | |
| 89 | 11.02 | Derrick JohnsonHoly Trinity | Holy Trinity '09 | NSCHSAA League Championships | 2008 |
| 90 | 11.02 | Raymond JonesRoosevelt | Roosevelt '14 | Section VIII Class County Championships | 2014 |
| 91 | 11.02 | Keshawn PinnockMalverne | Malverne | Section VIII State Qualifer Day 1 | 2025 |
| 92 | 11.03 | Richard AndersonMalverne | Malverne '14 | Knight Time Invitational | 2014 |
| 93 | 11.04 | Cleveland ModestUniondale | Uniondale '16 | Section VIII Class 3A County Championships | 2015 |
| 94 | 11.05 | Evans LinzeyKellenberg | Kellenberg '24 | NSCHSAA/NSCHSGAA League Championships | 2024 |
| 95 | 11.05 | Joseph VacchioLynbrook | Lynbrook '24 | Section 8 Division 3B Meet | 2024 |
| 96 | 11.05 | William HolmesElmont Memorial | Elmont Memorial | Section VIII County Championships Class AA | 2023 |
| 97 | 11.07 | Jerry EdwardsRoosevelt | Roosevelt '06 | Class A Championships | 2006 |
| 98 | 11.07 | Tyrell HolderBaldwin | Baldwin '26 | Division 1B Championship | 2026 |
| 99 | 11.08 | Jordan DeJesusWest Hemp | West Hemp '22 | Paul Limmer Invite at Mepham High School | 2022 |
| 100 | 11.08 | Alex FrankW. Tresper Clarke | W. Tresper Clarke '26 | Nassau Coaches Invitational | 2026 |